刺激频率耳声发射的产生机制及临床应用关键技术的研究

In order to study the mechanism of Stimulus-Frequency Otoacoustic Emissions (SFOAEs) and the key techniques for the quantitative diagnosis of sensory hearing loss with SFOAEs, this project established a quantitative model of SFOAEs generation mechanism and investigated the variation of each generation source of SFOAEs, through the decomposition of SFOAEs signal and the extraction of characteristic parameters from SFOAEs signals under different stimulus frequencies and intensities, and further clarified the mechanism of SFOAEs generation source with the frequency and intensity of stimulation. Then, based on the model of SFOAEs generation mechanism and the pure tone audiometry threshold, the quantitative mathematical relationship between the characteristic parameters of SFOAEs and pure tone thresholds was established, as well as the quantitative diagnosis model for sensory hearing loss. Finally, this project clarified the regularity of the contribution of each generation source of SFOAEs in the two models and their physiological mechanisms. The basic theoretical research of this project lays the foundation for the clinical application of SFOAEs as an objective and quantitative diagnostic tool for sensory hearing loss.

为了研究刺激频率耳声发射（SFOAEs）的产生机制和SFOAEs对感音性听力损伤进行定量诊断的关键技术。本项目通过对不同刺激频率和强度下的SFOAEs信号的分解和特征参数的提取；研究SFOAEs各个产生源的变化规律；建立SFOAEs产生机制的定量模型；澄清SFOAEs的产生机制随着刺激频率和强度的变化规律。然后，利用SFOAEs产生机制模型，基于纯音测听阈值，分别建立表征SFOAEs各个产生源的特征参数与纯音测听阈值之间的定量数学关系；对感音性听力损伤建立定量诊断的数学模型。最后，澄清SFOAEs的各个产生源在两个模型中贡献量的变化规律及其所蕴含的生理机制。本项目的基础理论研究为SFOAEs成为感音性听力损伤的客观、定量诊断工具奠定了临床应用的基础。

本项目在实施过程中依据本基金的项目任务书：为了挖掘SFOAEs的应用价值以推进其临床应用性，SFOAEs的产生机制和其与感音性听力损伤的关系在本项目中被进一步研究并取得重大突破。本项目首先通过研发并完善SFOAEs检测分析平台的软硬件设计，基于大量临床数据设计了适合本项目的人工神经网络，开拓了适用于临床的国际上首台“SFOAEs检测仪”；接着本项目通过对不同刺激频率和强度的SFOAEs信号进行分解和特征参数的提取，研究了SFOAEs各个产生源的变化规律，首次证实了精细结构出现的原因；然后，基于SFOAEs中所蕴涵的表征耳蜗性听力损伤的信息，我们建立了描述SFOAEs信号与纯音听力阈值间定量关系的数学模型，利用人工智能技术，首次提出基于SFOAEs对纯音听力阈值的预测；最后，我们澄清了SFOAEs不同产生机制的分量对预测纯音听力阈值的贡献量，及其所蕴含的生理机制，并将研究成果应用于“SFOAEs检测仪”中。本项目的基础理论研究为SFOAEs成为感音性听力损伤的客观、定量诊断工具奠定了临床应用的基础，而研究过程中开发的SFOAEs检测仪及相关应用技术显著推进SFOAEs向临床的应用。..本项目超额完成了各项指标，完整搭建了3台“SFOAEs检测仪”，发表论文12篇，被SCI收录8， 被EI收录2篇。申请及授权专利19，已经授权专利8项目，获奖共两项，其中国际级别获奖1项，国家级别获奖1项。