酰基化脑肠肽抑制脑缺血引起神经元凋亡的分子机制
基本信息
结项摘要
酰基化脑肠肽(ghrelin)是最近从胃中新发现的一种胃肠激素，它具有独特的辛酰基修饰结构。我们首先发现ghrelin注入大鼠侧脑室可对抗脑缺血引起的神经元损伤，并证明这种效应与其抑制神经元凋亡密切相关。本课题是在上述研究基础上，对ghrelin 的抑制脑缺血引起的神经细胞凋亡的分子机制进行深入研究。拟从神经细胞凋亡的启动因素、凋亡过程的级联反应重要分子及基因等不同环节，找出Ghrelin对脑缺血引起神经元凋亡抑制效应的靶环节和靶分子。阐明其抑制作用的分子机制。迄今为止，尚未见有关ghrelin 与脑缺血关系的研究报道。本研究结果不仅为ghrelin在CNS的新生物效应及机制提供实验依据；同时，对于补充和完善胃肠内分泌和脑之间的远距离功能联系的生理理论具有重要意义。此外，也为脑缺血临床防治的内源性保护策略提供有价值的资料。
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数据更新时间：2023-05-31
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