单序列多对比度颅颈一体高分辨率脑实质及血管壁磁共振成像方法研究

China has the greatest burden of cerebrovascular disease in the world. For patients with cerebrovascular disease, magnetic resonance imaging (MRI) is one of the most commonly used imaging method. Combined brain parenchymal lesion evaluation and vessel wall evaluation is beneficial for patients with cerebrovascular disease, which is conducive to the accurate diagnosis. However, the scan time of current high-resolution vessel wall imaging method is too long to use in clinical applications. This project proposes a single sequence multi-contrast technique for simultaneous high-resolution brain parenchyma and intra- and extracranial vessel wall imaging. To achieve the aim, two issues will be addressed: 1) sequence design for single scan multi-contrast technique for simultaneous high-resolution brain parenchyma and intra- and extracranial vessel wall imaging; 2) sparse sampling and joint multi-contrast reconstruction. This project aim to significantly reduce the scan time of brain parenchyma imaging and intra- and extracranial vessel wall imaging, promote the application of magnetic resonance high-resolution vessel wall imaging technology in routine clinical application, and realize one-stop examination for patients with cerebrovascular disease, which have important clinical significance.

中国是世界上脑血管病负担最大的国家。磁共振成像是最常用的脑血管病患者临床影像学检查手段之一。联合脑实质病变检查和高分辨血管壁成像能够为脑血管病患者提供丰富的影像学信息，有利于病情的精准诊断。然而目前高分辨磁共振血管壁成像时间过长，不适用于临床应用。为解决上述问题，本项目提出单序列多对比度颅颈一体高分辨率脑实质及血管壁磁共振成像方法。本项目主要研究内容包括：1）单序列多对比度颅颈一体高分辨率脑实质及血管壁磁共振成像序列设计；2）稀疏采样及多对比度图像联合重建。本项目的开展能够显著降低脑血管病患者临床磁共振脑实质成像及颅颈联合血管壁成像的时间，促进磁共振高分辨率血管壁成像技术在常规临床检查中的应用，实现脑血管病患者一站式三维高分辨率磁共振脑实质和血管检查，有利于脑血管病患者病因的精准诊断，具有重要的临床意义和应用前景。

中国是世界上脑血管病负担最大的国家。磁共振成像是最常用的脑血管病患者临床影像学检查手段之一。脑血管病磁共振检查常需要扫描多种图像对比度或定量图谱，往往需要较长的成像时间，从而在一定程度上影响其临床可及性和扫描成功率。本课题围绕着单序列多对比度成像要求，在技术方面，我们先后开发了多个单序列多对比度成像技术，在应用方面，我们分别进行了血管壁定性与定量评估、脑组织定量评估、肾脏灌注及定量评估等多场景进行了技术验证。项目实施期内，共发表SCI论文4篇，授权发明专利2项，国际磁共振大会摘要4篇，协助培养博士研究生4名。