全麻药对鼠脑c-fos表达、ATP酶和信号转导系统的影响

The mechanism of general anesthesia is one of the most important basic theories of anesthesiology, which has not been fully elucidated for the last century. This subject aims to throw light on the central effects of general anesthetics commonly used in the clinic by various means. Through three years study, it has been found that GABAA receptor and muscarinic receptor were not the key targets of general anesthetics. The changes of activities of ATPase or NOS and volume of cAMP precede and are parallel to the behavioral changes caused by general anesthetics, it indicates that they play a very important role in the central effects of general anesthetics. Cortical QPEEG can be altered by propofol in a dose-dependent manner, especially in the parietal lobe, so does the membrane fluidity of the neurons. The changes of neural membrane fluidity may be one of the mechanisms of general anesthesia. It can be concluded that the central effects of general anesthetics are characteristic of all-sites, multi-targets, specificity and non-specificity..

通过分子生物学、神经电生理学、生物化学与行为研究的有机结合，根据给予大鼠全麻药后的不同阶段，观察5种全麻药对鼠脑c-fos表达、钠离子通道、4条细胞信息转导系统的影响捌湎嗷ス叵担沂救橐┑淖饔貌课缓退承颉⑹挤⒃颉⒓谭⑿вΑ⒐丶方诤腿非谢疲魅樵怼⒅傅剂俅猜樽砗脱兄菩滦腿橐┨峁├砺垡谰荨