炎症过程中环加氧酶-2多态性表达调控机制及药物干预的研究
基本信息
结项摘要
本研究根据我们先前发现COX-2的剪接异构体COX-2b，并证实炎症过程中COX-2/COX-2b多态性表达的平衡与否决定炎症的不同转归这一新成果，用分子生物学、生物信息学及蛋白组学的方法，从整体、细胞和分子水平对COX-2/COX-2b多态性表达调控机制三个环节顺式剪接元件、反式剪接因子及信号分子和信号通路进行探讨，以寻找控制炎症过程中COX-2/COX-2b表达的关键平衡点。进一步针对其关键平
项目摘要
项目成果
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数据更新时间：2023-05-31
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