细胞内受体TLR9、NOD1和NOD2在不可分型流感嗜血杆菌肺组织感染中的作用
基本信息
结项摘要
不可分型流感嗜血杆菌（Nontypeable Haemophilus Influenzae，NTHi）是下呼吸道感染重要的细菌，可定植于胞内，成为再次感染的来源。TLR9和NOD1/NOD2均为细胞内胞浆受体，TLR9特异性识别细菌CpG-DNA，NOD1识别革兰氏阴性菌肽聚糖DMP，NOD2识别广谱细菌肽聚糖MDP而参与机体抗感染天然免疫。TLR 9与NOD1/NOD2在所介导的信号通路产生前炎症和抗炎症因子中具协同作用。我们通过肺组织体外NTHi急性感染模型，检测NTHi的胞内感染率和TLR9、NOD1/NOD2 mRNA、蛋白质及其信号通路分子的表达，同时应用脂质体和siRNA阻断实验了解肺泡巨噬细胞在NTHi内化中的作用和对TLR9与NOD1/NOD2表达的影响，从而为特异地调节炎症反应和维持适当的免疫反应的平衡提供新的分子靶标，为今后治疗NTHi提供新策略。
项目摘要
项目成果
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数据更新时间：2023-05-31
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