游离脂肪酸引起足细胞凋亡在早期糖尿病肾病微量白蛋白尿中的作用和机制探讨
基本信息
结项摘要
糖尿病肾病(DN)是全球面临的严重的医疗、社会和经济问题，使早期DN的防治成为研究的核心。随脂毒性学说揭示游离脂肪酸脂毒性引起2型糖尿病发生，体外研究脂肪酸与胰腺β细胞、肝细胞、成心肌细胞作用触发内质网应激引起细胞凋亡的结果迅疾涌现，恰如对内质网应激引起细胞凋亡广泛参予多种疾病的认识的飞速深入。内质网应激在DN发生和进展中的作用尚无研究。当肾脏病学家发现足细胞凋亡伴随蛋白尿和肾小球硬化而行，动物实验证实足细胞凋亡是早期DN的突出表现。通过本研究，希望揭示2型糖尿病患者早期DN时存在显著的足细胞凋亡，游离脂肪酸是引起早期DN患者的重要因子之一，它可能通过触发内质网应激引起足细胞凋亡发挥致病作用，尽早使用非诺贝特降低脂肪酸水平可以延缓或减轻早期DN的发生和进展。
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数据更新时间：2023-05-31
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