多模态MRI对2型糖尿病小型巴马猪胰腺病变的病理对照研究及临床应用

Type 2 diabetes is a serious threat to human health and brings about a series of social problems, due to its high morbidity and harmfulness. The main pathological feature of type 2 diabetes is the hypofunction of islet β-cell. Researchers show that destruction of the islet structure, pancreatic fatty infiltration and fibrosis formation is closely related to islet β-cell hypofunction and the occurrence of type 2 diabetes. However, the noninvasive examination methods to accurately assessment of pancreatic pathological changes are still lacking. . Because of MRI could make an accurate assessment of the degree of fatty infiltration and fibrosis. Our project is intended to establish a model of type 2 diabetes in Bama pig, the application of multimodal MRI sequences (including DKI, IVIM and DEAL - IQ sequences) to scan of the pancreas, then we can obtain quantitative parameters of each sequence, and different duration period of pancreatic pathology results (including the degree of islet cell apoptosis, pancreas fatty infiltration and fibrosis) for control study. Our project will study the pancreatic quantitative parameters of multimodal MRI, the pathological features and the severity. And then we will apply this scan scheme in patients with type 2 diabetes, establish the corresponding prediction model, which is expected to provide a noninvasive, convenient, accurate examination method for early diagnosis and efficacy evaluation of pancreatic pathological features and prognoses in patients with type 2 diabetes mellitus. Ultimately, the project could provide basis for the selection of clinical targeted therapy and improvement of long-term prognoses.

2型糖尿病由于较高的发病率和危害性，严重威胁人类健康并带来一系列社会问题，它的主要病理特征是胰岛β细胞功能减退。研究表明，胰岛细胞凋亡、胰腺脂肪浸润、纤维化形成与胰岛β细胞功能减退和2型糖尿病的发生、发展关系密切，但是对于其胰腺病理改变的准确评估至今缺乏一种无创性的检查方法。. 由于MRI可以对脂肪浸润和纤维化程度做出较为准确的评估，本项目拟通过建立2型糖尿病巴马猪模型，应用多模态MRI序列（包括DKI、IVIM和DEAL-IQ）对其胰腺进行扫描，获得各序列的定量参数，与不同病程时期的胰腺病理结果进行对照研究。本项目将研究胰腺MRI扫描获得的各定量参数所反映的病理特征及病变程度，并将该扫描方案应用于2型糖尿病患者，建立相应的预测模型，从而期望能够提供一种无创、便捷、精准的检查方法，为患者胰腺病理改变的早期诊断、预后判断及疗效评估提供参考，为临床治疗靶点的选择及改善远期预后提供依据。

2型糖尿病由于较高的发病率和危害性，严重威胁人类健康并带来一系列社会问题，它的主要病理特征是胰岛β细胞功能减退。研究表明，胰岛细胞凋亡、胰腺脂肪浸润、纤维化形成与胰岛β细胞功能减退和2型糖尿病的发生、发展关系密切，但是对于其胰腺病理改变的准确评估至今缺乏一种无创性的检查方法。本项目通过建立2型糖尿病巴马猪模型，应用多模态MRI序列对其胰腺进行扫描，获得了胰腺脂肪含量的定量参数，然后与不同病程时期的胰腺病理结果进行了对照研究，验证了MRI对于胰腺脂肪定量的准确性，并明确了糖尿病动物模型中，胰腺脂肪浸润程度与血糖、血脂代谢的相关性。此外，本项目对采用MRI脂肪定量技术对2型糖尿病患者的胰腺脂肪进行了定量分析，并且与肝脏脂肪沉积、腹部脂肪面积、血糖、血脂等代谢指标进行了相关性研究。通过上述研究为糖尿病患者胰腺脂肪浸润的病理改变提供了无创性评估手段，为潜在的临床干预方案提供了可行的监测方法。