“导航型”磁性半导体纳米药物的构建及其在肿瘤光热化疗中的应用

Semiconductor nanoparticles with good optical properties and outstanding thermal stability has recently become a hot spot in nanomedicine research field. However, how to make it more excellent performance by further doping, surface modification, and structure modification, so as to achieve multifunctional nanoparticles with tumor theranostics, still needs further exploration. . Based on the earlier studies, this project aims to design and synthesize the hollow porous structure magnetic semiconductor nanoparticles [CuMSx (M=Fe, Co, Mn)] with loading chemotherapeutic drugs, and then core-shell structure CuMSx@UCN nanoparticles were constructed by self-assembly between CuMSx nanoparticles and rare earth conversion nanoparticles (UCNPs), finally, the iRGD pepite, targeting to liver cancer cells, was modified on the surface of UCNPs to construct nanodrugs with intelligent and tumor theranostics. Such nanodrugs were used to visually treat tumor by photothermal-chemical therapy at lesions or target site under magnetic resonance imaging/fluorescence/infrared thermal imaging navigation. . The completion of the project will provide theoretical guidance and experimental data for the research and development of new semiconductor nanocomposites that were used photothermal-chemical therapy, simultaneous diagnosis and treatment, and real-time monitoring treatment of tumor, and provide important scientific basis for chemical treatment combined with photothermal therapy to conquer liver cancer.

半导体纳米粒子具有良好的光学特性和突出的光热稳定性，成为了当今纳米医学领域研究的热点。然而，如何进一步通过掺杂、表面修饰、结构改造使其性能更加优异，从而达到多模式诊疗一体化的多功能纳米粒子仍然有待进一步探索。. 本项目拟在前期研究基础上设计合成空心多孔磁性半导体纳米粒子[CuMSx (M=Fe, Co, Mn)]，其空心结构用于装载化疗药物, 然后CuMSx和稀土上转换纳米粒子（UCNPs）通过程序化自组装得到CuMSx@UCNPs核壳结构纳米粒子，最后靶向肝癌的iRGD 肽修饰在UCNPs表面得到智能型诊疗一体化的纳米药物，用于对病灶或目标部位磁共振/荧光/红外热多模式像成像导航下可视化肿瘤药物及光热协同治疗。. 此项目的完成，对研究开发新型纳米半导体复合材料用与光热化疗、诊断同时治疗、治疗实时监测提供理论指导和实验数据，并为光热化疗联合使用攻克肝癌提供重要的科学依据。

诊疗是一种近几年发展起来的癌症诊治新方法，它将多模式的成像技术和成像引导下的治疗有机结合在一起，使得对癌症的高效和个性化诊治成为可能。本研究在这一背景及申请的国家基金委项目的资助下在多功能纳米探针和纳米药物的合成及癌症的诊疗等方面取得了一系列的进展。研究内容以申报的课题为指导，在相关的复合材料的合成、表面修饰和组装、癌症的多模式检测和成像以及药物载体方面做了一系列工作。在课题进展过程中我们也对癌细胞检测的方法进行了创新。同时在项目实施过程中，我们也对与肿瘤相关的其它目标物检测方面做了初步的探索。项目按照原计划圆满完成，后继的一些延伸性的工作在继续探索中。以上项目的完成，为无机纳米探针在肿瘤早期检测、多模式成像和治疗领域的应用提供一定的理论依据和实验基础。