肿瘤αvβ3受体显像与核素靶向治疗的实验研究
基本信息
结项摘要
研究内容：合成αvβ3受体拮抗剂RGD-4CK，并与DTPA偶联形成DTPA-RGD-4CK，利用放射性核素99m锝(99mTc)和188铼(188Re)标记，作为αvβ3受体的放射性配体；研究99mTc（188Re）-DTPA-RGD-4CK的最佳标记条件；研究标记配体的理化和生物学性质、体内药物动力学与体内代谢行为；研究标记配体与肿瘤αvβ3受体的体内、外结合特性；建立99mTc标记配体对荷瘤
项目摘要
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数据更新时间：2023-05-31
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