蛋白质拓扑结构的识别、构建和预测

Based on protein secondary structure sequence the recognition and architecture of protein framework structure are studied. The laws governing the alpha helix and beta strand clustering in a globular protein are discovered. The concept on compact structural domain is proposed. The five kinds of structural class of globular protein can be defined in terms of three kinds of compact structural domain. The sequence redundancy is investigated. The prediction rules on structural class and topological structure are given at a higher accuracy.

从日益增长的蛋白质结构资料出发，分析二级结构序列和蛋白质折迭型及拓扑结构的关系，在识别折迭型及拓扑结构的基础上，寻找蛋白质框架结构的基本模式，求出从序列资料预测拓扑结构的经验规则，并从理论上给出这些规则的结构学基础。估计拓扑结构预测的成功率可达９０％，从而为研究氨基酸序列及蛋白质框架结构关系这一方向提供独特的研究成果。