DNA聚合酶β与食管癌癌变机理关系的研究
基本信息
结项摘要
本次申请项目是已结题的国家自然科学基金资助项目的延续，旨在进一步深入探讨食管癌POLB基因与癌基因、抑癌基因三者之间的关系，以及其与微卫星DNA不稳定性之间的关系。构建不同的POLB(野生型和突变型)表达质粒，并转染NIH3T3细胞、JB6细胞Eca-109细胞和POLB缺失型细胞株，通过对AP位点、环境诱变剂诱导的突变的特点和频率、细胞的正、逆向转化等进行检测和分析，继续研究POLB基因突变在食管癌发病中所起的作用，试图寻找一批针对性强的POLB基因的生物调节剂，干预POLB基因在正常和肿瘤细胞中的表达，通过稳定调节其表达，提高肿瘤化疗药物的疗效，降低食管癌的发生率，减缓癌症的进程，使我国在食管癌病因研究、预防和治疗领域处于国际领先地位。
项目摘要
项目成果
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数据更新时间：2023-05-31
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