Curcumin通过E-cadherin介导的PS-1/E-cadherin/β-catenin复合物防治AD的机制研究
基本信息
结项摘要
Wnt/β-catenin通路信号分子的改变和Aβ的聚集均与AD发生密切相关，该通路的负调节剂Curcumin可防治AD，但具体机制不清。结合前期研究，我们提出"Curcumin通过E-cadherin介导的PS-1/E-cadherin/β-catenin复合物防治AD"。本课题首先以稳定表达APP695sw的单细胞克隆神经细胞系N2AP1为研究对象，采用免疫荧光、免疫共沉淀、蛋白印迹等方法观察
项目摘要
项目成果
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数据更新时间：2023-05-31
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李昱的其他基金
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相似国自然基金
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