PRL-3促肿瘤转移的信号通路与新型抗转移药物的评价
基本信息
结项摘要
在PRL-3（phosphatase of regenerating liver-3）低表达(低转移)黑色素瘤细胞株B16中转入正常或突变PRL-3基因，构建B16-PRL-3、B16-PRL-3m细胞株，在PRL-3高表达(高转移)的B16-BL6中用RNAi技术构建B16-BL6-PRL-3-down细胞株。以此为平台，在分子和细胞水平上证实PRL-3通过与Src结合活化整合素信号通路及上调整
项目摘要
项目成果
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数据更新时间：2023-05-31
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曹少先的其他基金
相似国自然基金
抗肿瘤转移新型药物的研究
整合素β1介导PRL-3促肿瘤转移的分子机制研究
转移相关新靶分子PRL-3在肿瘤转移中的作用及其机制
新型超分子前体药物体系的构建及抗转移性肿瘤研究