仿生配体修饰磁性纳米颗粒的可控制备与改性研究

It is essential to tune the physicochemical properties of magnetic nanomaterials for their applications in the fields of catalysis, optics, magnetic medium, and biomedical diagnosis and therapy. The aim of this project is to intensive study the relationship of surface/interface structure and functional groups of marine mussel surface based on the molecular level and nano scale, which surface plays a key role in specific adhesion properties. And, to design and synthesize multidentate biomimetic ligands with chitooligosaccharide as a scaffold, and form self-assembled monolayers on the surface of magnetic nanoparticles in order to tune the physicochemical properties of nanoparticle furfaces, such as surface chemical structure, hydrophilicity, hydrophobicity, chemical adsorption and reaction properties. This research will exploit a simple synthetic strategy which not only renders the nanoparticles dispersibility and ultrastable with respect to aggregation and high magnetic properities, but also imparts functionality through which additional features can be introduced. To investigate the correlation of nanoparticles' characteristics and biomimetic ligand molecules by using FTIR, XRD, XPS, TEM, DLS, VSM, TGA and other means. To explore new methods in self-assemble process of biomimetic ligands on the nanoparticle sufaces. To study the controllable preparation, modification principle,and technical requirement of magnetic nanoparticles using multidentate biomimetic ligands.

解决磁性纳米颗粒的分散性、稳定性和功能化问题是实现磁性纳米颗粒在催化、滤光吸收、磁介质、生物医药等前沿领域实际应用的最迫切课题。本项目从分子和纳米尺度深入研究对特异粘附性能起关键作用的海洋蚌类表面、界面结构与功能基团的联系，设计合成基于壳寡糖骨架分子的多齿仿生配体，并在纳米颗粒表面进行自组装修饰以改变颗粒表面的物理化学性质，如表面化学结构、表面亲疏水性、化学吸附和反应特性等，制备具有良好分散性、稳定性及强磁性能的纳米颗粒，运用FTIR、XRD、XPS、TEM、DLS、VSM、TGA等手段考察纳米颗粒的性状及其与仿生配体分子之间的相互作用，探索多齿仿生配体与纳米颗粒表面自组装中所涉及的新方法，开展仿生配体稳定剂增强的纳米颗粒的可控制备与表面活性分子改性原理和技术研究。

磁性纳米颗粒在生物医学领域的应用需要其具有良好的胶体稳定性和生物相容性，同时也需要在其表面修饰上各种生物分子或连接各种生物分子的化学官能团。解决磁性纳米颗粒的分散性、稳定性和功能化对制备功能化的纳米颗粒和提高制备质量具有重要意义。本项目主要开展了基于壳寡糖骨架分子的多齿仿生配体设计合成方法和磁性纳米颗粒表面功能化研究。本项目围绕磁性氧化铁纳米颗粒与配体的相互作用研究，系统开展并取得了如下创新性研究成果：1）建立了具有多重相互作用的基于壳寡糖的多齿仿生配体的合成及表征方法；2）建立了仿生配体修饰磁性纳米颗粒的可控制备方法，并揭示了纳米颗粒与配体的相互作用的机理；3）研究了仿生配体修饰的磁性氧化铁纳米颗粒的磁共振对比增强效果，完成了纳米颗粒作为磁共振造影剂的体内成像研究；4）完成了多尺度纳米结构的构建、表面功能化以及无机纳米探针研究。在项目执行期间，项目组共发表学术论文8篇，申请专利4项，圆满完成了项目计划任务。