主客体相互作用调控的聚合诱导自组装

Polymerization induced self-assembly is a technique using "living"/controlled dispersion polymerization or emulsion polymerization to synthesis self-assemblies of amphiphilic block copolymer simultaneously during the polymerization, thus realize the preparation of micelles, worm-like micelles, vesicles and various morphology assemblies with high concentration and controllable synthesis. The aqueous phase dispersion polymerization of hydrophobic monomers is the direction of great development and great challenge. This project aims to establish common synthesis methods to realize the supramolecular host-guest interaction aqueous dispersion polymerization, and achieve the accurate preparation of high concentration polymer assemblies. The functional groups and functional monomers will be introduced, and the multilevel structure and the functional assembly of different morphologies will be prepared by the polymerization induced assembly controlled by the subject and object, and the properties of the assembled body were controlled. Controlled preparation of reactive assembly and stimulation of responsive assemblies will be studied, and regulating its reactivity and stimulation responsiveness will be reached. The preparation of new functional nano-assembly materials will be explored, the functions of nanometer reactor, drug controlled release, detection, and catalysis will be realized. This project is devoted to the subject role in regulating aqueous phase polymerization induced self-assembly, with high concentration of high reproducibility of controllable preparation of functional polymer assemblies, and will reveal the structure-activity relationship of structure and performance of polymer. It has important scientific significance and wide applications.

聚合诱导自组装是利用“活性”/可控分散聚合或乳液聚合的手段在实现两亲嵌段共聚物聚合的同时进行自组装，从而实现胶束、蠕虫状胶束、囊泡等多种形貌组装体的高浓度可控制备。疏水单体的水相分散聚合诱导组装是其中需要大力发展又面临巨大挑战的方向。本项目旨在结合超分子化学，通过主客体相互作用实现适用于疏水单体的水相分散聚合诱导自组装，建立通用的合成方法，水相可控制备高浓度聚合物组装体；引入功能基团和功能单体，利用主客体调控的聚合诱导组装可控制备多层次结构、不同形貌的功能组装体，调控组装体的性质；可控制备刺激响应性组装体，调控其刺激响应性；探索新型功能纳米组装材料的制备，以实现纳米反应器、载药控释、检测、催化等多方面的功能。本项目致力于主客体作用调控水相聚合诱导自组装，高浓度高重现性地可控制备功能化的聚合物组装体，揭示聚合物多层次结构与性能的构效关系，具有重要的科学意义和宽广的应用前景。

聚合诱导自组装是利用“活性”/可控分散聚合或乳液聚合的手段在实现两亲嵌段共聚物聚合的同时进行自组装，从而实现胶束、蠕虫状胶束、囊泡等多种形貌组装体的高浓度可控制备。疏水单体的水相分散聚合诱导组装是其中需要大力发展又面临巨大挑战的方向。本项目结合超分子化学，通过主客体相互作用实现适用于疏水单体的水相分散聚合诱导自组装，建立了通用的合成方法，水相可控制备了高浓度聚合物组装体；引入功能基团和功能单体，利用主客体调控的聚合诱导组装可控制备多层次结构、不同形貌的功能组装体，调控组装体的性质；可控制备了刺激响应性组装体，调控其刺激响应性；探索了新型功能纳米组装材料的制备，以实现纳米反应器、载药控释、检测、催化等多方面的功能。本项目致力于主客体作用调控水相聚合 导自组装，高浓度高重现性地可控制备功能化的聚合物组装体，揭示合物多层次结构与性能的构效关系，具有重要的科学意义和宽广的应用前景。