TGFβ2特异性dsRNA在青光眼滤过泡瘢痕化防治中作用的研究
基本信息
结项摘要
青光眼是一种最常见的不可逆性致盲眼病，目前治疗仍然是以手术降低眼压为首选方法。Tenon's囊成纤维细胞过度增殖导致的术后滤过泡瘢痕化是青光眼滤过性手术失败的主要原因。近来研究显示TGFβ2在青光眼滤过泡瘢痕形成过程中具有重要作用。为此，我们设想能否利用新兴的RNA干预（RNA interference,RNAi）技术，通过合成针对TGFβ2特异性双链RNA(dsRNA),构建其载体，转染Tenon's囊成纤维细胞，在mRNA水平实现特异高效阻抑Tenon's囊成纤维细胞TGFβ2的合成，在细胞和活体水平研究TGFβ2特异性dsRNA对成纤维细胞的抑制作用和对青光眼手术后滤过泡瘢痕化的防治效果及其机制。目前国内外尚无类似研究报道。本研究结果将为防治青光眼滤过泡瘢痕化寻找一种新的方法，以期为提高青光眼滤过性手术成功率提供一种新策略。
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数据更新时间：2023-05-31
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