基于模型化合物的蛋白胶黏剂改性机理研究

The development of bio protein-based adhesive is an important tendency in wood panel industry. However, since protein-based adhesive normally is prepared by a material being rich of protein, which is a complex mixture with kinds of ingredients and with intricate chemical structures, the study on its modification mechanism is very difficult. Actually, more attentions have been put on the its application rather than its chemistry seen from most of reports on protein-based adhesive. .On the basis of our previous work on protein-based adhesive, some amino acids, di-peptides and polypeptides will be used as model compounds to react with some effective modifiers of protein-based adhesive and to study their modification reaction. By the calculation based on the theory of quantum chemistry, some information on the reaction conditions and its happening between reactive groups and kinds of modifiers, the micro reaction process, performances of the reaction products and the competition between reactive groups will be given. .By the analysis of the chemical structure of the reaction products, the formation of their structure will be studied. Therefore, the reaction mechanism with protein model compounds and modifiers will be explored. The effects of reaction conditions on the reaction products and the key factors will be found. The optimized reaction conditions will be given on a specific modifier and proteins. With the help of the results on the performance of protein-based adhesive prepared from soy protein isolate, the mechanism with protein model compounds and modifiers will be examined and be more appropriate. .The objective of this work is to breakthrough the bottleneck of the past studies on the mechanism of the preparation of protein-based adhesives and then be useful to its modification and application.

蛋白胶黏剂是目前木材胶黏剂的重要发展趋势，但由于蛋白分子成分多样，结构复杂，改性机理研究难度较大，相关研究多局限于技术开发，基础理论研究相对匮乏。本项目在前期蛋白胶黏剂改性研究基础上，以组成蛋白的特定氨基酸、二肽、多肽为模型化合物，利用量子化学理论计算，提供蛋白分子官能团与不同改性剂之间的反应条件、微观反应历程、产物性质、反应竞争性等信息；利用结构分析方法，明确改性产物结构特征，揭示产物结构形成过程；综合两种分析方法结果，解析蛋白质模型化合物与不同改性剂的反应机理，明确反应条件对蛋白分子改性产物结构的影响和决定机制，优化反应条件；通过大豆分离蛋白胶黏剂性能研究，进一步验证和完善蛋白胶黏剂改性机理。本项目旨在突破蛋白胶黏剂改性理论瓶颈，为蛋白胶黏剂的制备工艺提供理论指导。

本项目针对蛋白胶黏剂研究多局限于技术开发而基础理论研究相对匮乏问题，在前期蛋白胶黏剂改性研究基础上，以组成蛋白的特定氨基酸、二肽、多肽为模型化合物，研究了蛋白分子模型化合物与甲醛、乙二醛、糠醇、环氧树脂、酚醛树脂等改性剂之间的反应机理，明确反应条件特别是pH值等对蛋白质分子反应活性基团与改性剂反应性的影响，并通过大豆蛋白基胶黏剂性能研究，明确反应条件对蛋白分子改性产物结构的影响和决定机制，优化了蛋白基胶黏剂制备条件。本项目的执行，进一步明确了蛋白基胶黏剂改性机理，突破蛋白胶黏剂改性理论瓶颈，为蛋白基胶黏剂的制备工艺提供了理论指导。自项目实施以来，正式发表相关研究论文16篇，其中，SCI收录论文6篇，中文核心期刊论文9篇。授权发明专利2项。培养硕士研究生3人，2人晋升上一级职称，1人入选国家级人才项目，3人入选省级人才项目。