抗肺癌药物肺靶向性微球的研究
基本信息
结项摘要
用二步法制得流动性好、吸湿性小、稳定性深兰色粉未状的米托蒽醌明胶微球。球内含量为8.17%。带正电荷，其粒径5.1-2.50um占总数87.6%，体外释药符合一级动力学规律，与原药比释药t1/2延长4倍，小鼠体内分布到肺的药量经原药增加6.4倍，分布到心脏减少80%，肺的相对摄取率最大，肺的靶向效率增在3-35倍，在肺内符合一室模型，与原药比其消除半衰其从7.8h延长到27h，平均滞留时间37h延长到47h，清除率降低68%。在血中符合三室模型，与原药比其消除半衰期从74.8h延到132.5h，消除率降低23%，。对小鼠肺部S-180肿瘤的抑瘤率（60%）与原药的剂量减半时相当。成功地制成小鼠静注后药可浓集于肺，对S-180肿瘤抑瘤率高，降低心脏副作用的肺靶向给药系统。
项目摘要
项目成果
{{i.achievement_title}}
{{i.achievement_title}}
暂无此项成果
数据更新时间：2023-05-31
其他相关文献
Ordinal space projection learning via neighbor classes representation
Ordinal space projection learning via neighbor classes representation
基于纳米铝颗粒改性合成稳定的JP-10基纳米流体燃料
基于纳米铝颗粒改性合成稳定的JP-10基纳米流体燃料
Image super-resolution based on sparse coding with multi-class dictionaries
Image super-resolution based on sparse coding with multi-class dictionaries
Phosphorus-Induced Lipid Class Alteration Revealed by Lipidomic and Transcriptomic Profiling in Oleaginous Microalga Nannochloropsis sp. PJ12
Phosphorus-Induced Lipid Class Alteration Revealed by Lipidomic and Transcriptomic Profiling in Oleaginous Microalga Nannochloropsis sp. PJ12
Numerical investigation on aerodynamic performance of a bionics flapping wing
Numerical investigation on aerodynamic performance of a bionics flapping wing
陆彬的其他基金
相似国自然基金
抗肝癌药物肝靶向性毫微球的研究
磁靶导向性形状记忆复合微球的血管栓塞机制
载顺铂的靶向性药物控制释放传输系统联合抗血管新生药物治疗肺癌
Fe3O4@PPy复合微球的制备及药物控释与靶向性能研究