Taxane compounds are unique terpenoid active ingredients of forest resources with significant anti-tumor activity in Taxus. Due to their low content in Taxus, and the difficulties for the separation and purification, new types of biomimetic molecularly imprinted materials for taxane compounds would be designed and constructed in this project. The cellulose is used as the bio-based material, and a series of new functional monomers are designed and synthesized. The hydroxyl groups on the cellulose surface would be modified and grafted. Baccatin III with the specific structure of taxane central framework is selected as template molecule, the surface molecular imprinting would be constructed on the surface and in the pore structure of porous cellulose matrix, novel kinds of green, highly efficient and regenerable micropore cellulose-based molecularly imprinted polymer (MC-MIP) for taxane compounds would be prepared. The adsorption and desorption capacity, selective identification ability for taxane compounds and structural characteristics of the obtained MC-MIP would be evaluated, screened and characterized. The theoretical models based on chemical kinetics and thermodynamics are established, then the molecular recognition mechanism of MC-MIP to taxane compounds would be studied preliminarily. Briefly, the study of this project would provide a sequence of novel micropore cellulose-based molecularly imprinted polymers for the targeted recognition and separation of taxane compounds and supply importantly scientific theory basis for the research of cellulose bio-based biomimeticly molecular imprinted materials.
紫杉烷类成分是红豆杉中具有显著抗肿瘤活性的林源萜类活性成分。针对紫杉烷含量低、分离纯化困难等问题,本项目设计并构建一种对紫杉烷类化合物具有特异性识别的仿生分子印迹材料。以纤维素为生物基材料,设计合成系列新型功能单体,对纤维素表面羟基进行改性接枝,以具有紫杉烷母核特异性结构的巴卡亭Ⅲ为模板分子,在多孔纤维素基质表面及孔结构中构建紫杉烷类成分分子印迹,制备一种绿色、高效、可再生的多孔纤维素基紫杉烷类成分分子印迹材料(MC-MIP)。对获得的MC-MIP进行紫杉烷类成分的吸附与解吸附能力、选择性识别能力和结构特征等系列评价、筛选和表征,从化学动力学和热力学角度构建理论模型,初步探讨MC-MIP与紫杉烷类化合物的分子识别机制。本项目的研究将为紫杉烷类成分的分离纯化提供系列具有靶向性识别的新型多孔纤维素基分子印迹材料,为纤维素生物基仿生分子印迹材料的构建提供重要的科学理论基础。
紫杉烷类成分是红豆杉中具有显著抗肿瘤活性的林源萜类活性成分。针对紫杉烷含量低、分离纯化困难等问题,本项目设计并构建一种对紫杉烷类化合物具有特异性识别的仿生分子印迹材料。以纤维素为生物基材料,设计合成系列新型功能单体,对纤维素表面羟基进行改性接枝,以具有紫杉烷母核特异性结构的巴卡亭III为模板分子,在多孔纤维素基质表面及孔结构中构建紫杉烷类成分分子印迹,制备一种绿色、高效、可再生的多孔纤维素基紫杉烷类成分分子印迹材料(MC-MIP)。对获得的MC-MIP进行紫杉烷类成分的吸附与解吸附能力、选择性识别能力和结构特征等系列评价、筛选和表征,从化学动力学和热力学角度构建理论模型,初步探讨MC-MIP与紫杉烷类化合物的分子识别机制。本项目的研究将为紫杉烷类成分的分离纯化提供系列具有靶向性识别的新型多孔纤维素基分子印迹材料,为纤维素生物基仿生分子印迹材料的构建提供重要的科学理论基础。
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数据更新时间:2023-05-31
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