大鼠骨骼肌肌浆网非核DNA结合蛋白的生理及病理意义

Based on the verifying the existing of non-nuclear DNA binding proteins in skeletal muscle sarcoplasmic reticulum， the structure and function of non-nuclear DNA binding proteins were investigated.The effect of sarcoplasmic reticulum Ca2+ transpot（including uptake and release）and calcium homeostasis with the binding of the protein and extrinsic DNA was firstly tested. The mechanism was estimated.The physiological and pathophysiological significance of the protein was illuminated.

非核DNA结合蛋白的重要意义正日益引起人们的关注，但其结构和生物学功能尚待阐明。本翁庠谥な荡笫筮蛇山屑〗嬖谟蟹呛薉NA结合蛋白的基础上，旨在研究该蛋白的结构并首次提出开展该蛋白与外源DNA结合后对肌浆网钙摄入与释放功能和胞浆钙稳态的影响及其机频难芯浚圆鞲玫鞍椎纳砑安±硪庖濉