新疆维、哈、汉族高血压流行病和中医证候调查及与BMI关系研究——基于数据挖掘和HLM模型构建与分析

Hypertension is situated the front row in chronic non-infectious diseases, which can cause heart and cerebral vessels, nephropathy and other chronic diseases. While the Obesity, overproof BMI and the hyperlipidemia are the important risk factor in causing hypertension. It is the important way to control body weight in hypertension prevention and control measures. And the BMI is the important standard to judge obesity levels. Under the TCM syndrome perspective, this study intends to research the hypertension, the BMI, the hyperlipidemia and the obesity ,and to explore and analyse the numerical relationship between the hypertension, overproof BMI, the hyperlipidemia, the incidence of obesity and TCM syndrome and type in Xinjiang ethnic group. The study will objectively present the regularities of distribution and the relationship among the hypertension, the hyperlipidemia, the incidence of obesity and TCM syndrome and type in Xinjiang, and the otherness in nationality, gender, age and region. To discuss the relationship between the BMI and the TCM syndrome and type of hypertension, the hyperlipidemia and obesity in Uygur, Kazahk and Han nationality, and then to present the numerical relationship , finally to construct the HLM about the BMI of hypertension group between different nationalities and the TCM syndrome and type of .On the basis of the HLM to predict the incidence of the hypertension, the hyperlipidemia and obesity in Xinjiang, and lay the theoretical and realistic foundation for the cure of the hypertension by combined the traditional Chinese and Western medicine.

高血压在慢性非感染性疾病谱中位居前列，可诱发心脑血管、肾病及其他多种慢性疾病，而肥胖、BMI值超标、高血脂是引起高血压的重要危险因素，在高血压防控措施中，控制体重是其重要途径，BMI值是判断肥胖水平的重要标准，本研究从“中医证候说”的视角对高血压、BMI指数、高血脂、肥胖症相关领域进行研究，拟探析新疆族群高血压、BMI值超标、高血脂、肥胖发生率及与中医证候、证型之间的数量关系。客观呈现新疆高血压、高血脂、肥胖的发病率及中医证候、证型分布规律，不同民族、性别、年龄、地域的差异性，分析相互之间的关系，探讨维、哈、汉族高血压、高血脂、肥胖症人群中医证候、证型和BMI指数间的关系，进而呈现其数量关系，最终构建不同民族高血压人群BMI指数与中医证候、证型间的HLM模型，并根据模型预测新疆今后高血压、高血脂、肥胖的发病率走向，为中西医结合防治高血压铺垫理论和实践基础。

高血压在慢性非感染性疾病谱中位居前列，是引起心脑血管、肾病、糖尿病等多种疾病的高危因素。新疆属于全国高血压发病率较高的地区，高血压病严重危害着边疆人民的健康，故需针对高血压患者开展综合干预。本研究经流行病学调查、临床及生化检查，共筛选纳入8828例符合高血压诊断的样本资料，以BMI指数、血压、血脂和中医证候分布规律及水平呈现新疆维、哈、汉族的体质与中医证型间的关系，借助数理模型考察相关研究对象高血压、高血脂、超重/肥胖症、BMI指数和中医证候、证型之间的数量关系，建立数理模型，并通过模型预测维、哈、汉族的高血压、肥胖症、高血脂发生率与中医证候、证型关系的走向。研究结果表明：（1）超重/肥胖、高血脂是引起高血压的重要危险因素；随着时代变迁，新疆地区维、哈、汉族的BMI值超标、肥胖、高血压、高血脂症发病率呈低龄化态势；（2）肥胖症及高血压、高血脂发病率在民族和年龄变量上存在显著差异，且发病率具有年龄聚集性；（3）超重/肥胖是高血压发生的重要因素，高血压分级与BMI存在显著相关性，其关联度在新疆各民族间存在差异；（4）血压分级及肥胖级别与中医证候、证型三者存在数量关系，呈现显著相关。