治喘贴促进哮喘机体Eos凋亡、对Eos、IL-5的调节作用

The project applied technologies of molecbiology、immunology、patholigy,in new perspective ,to explore regulation of ZhiChuanTie（ZCT）to Thymus second group ，promotement to eosinophils（EOS），regulation to EOS and the levels of Interlenkin-5（IL-5）、Interlenkin-2（IL-2），so as to study the effect of ZCT on child asthma patients .Animal experiment showed that ZCT could lower the level of EOS in the bronchus alveoli lavage fluid(BALF) of experimental rats ,induce EOS of asthma rats ,reduce the amount of IL-5 in blood ,increase the amount of IL-2 in blood ,and promote the proliferations of thymus cell .Biopsy showed that in treatment group , inflammatory cells reduced in experimental rats'lung , inflammation improved ,the conformation of bronchial tubes were stable ,inflammatory exudates was reduced in tubes .Clinical research showedtreatment group was better than control group in symptom improve and the frequency of recur.The amount of EOS、IL-5 in peripheral blood and puta were both lower than that of before treated .The amount of CD4 in peripheral blood decreased while CD8 increased .Conclusion could be drawn that ZCT could improve body immunity which had a reliable effect on asthma.

本研究在总结过去研究中药治喘贴治疗儿童哮喘的基础上，从新的角度运用分子生物学、免疫学、病理学技术，研究该药对哮喘机体、T细胞亚群调节、促进Eos凋亡，对Eos与IL-5的鹘谧饔茫床髦未瘟贫拿庖哐Щ疲佣俅蔡峁├砺酆褪导谰荨