光热协同短距离放疗治疗胰腺癌研究

How to effectively enhance the specificity of deep tumor tissue to radiotherapy and reduce the damage to normal tissue is a key scientific problem that needs to be solved in clinical radiotherapy. In view of this, the applicant intends to construct nano-liposome gold capsules for the combination of photothermal and short-distance radiotherapy for pancreatic cancer treatment. In this therapy, nano-liposomal gold capsules are used both as photothermal agents and radiotherapy sensitizers, which are specifically targeted to pancreatic cancer by intravenous injection through blood circulation; radioactive iodine 125 seeds are implanted into pancreatic cancer as short-distance radioactive sources; near-infrared laser fiber passes through a customed hollow PTC puncture needle into the abdominal cavity to provide the light source for minimally invasive hyperthermia. Upon the near infrared laser irradiation, liposomes gold capsules can not only convert light energy into heat to kill tumor cells, but also enhanced radiotherapy dose of iodine 125 seeds through the excitation- deexcitation process to produce secondary charged electrons and radiation photons, in addition, the photothermal effect can cause the collapse of nano-liposome capsules, inducing its decomposition to small components which is suitable for the clearance from kidneys. This therapy is expected to expand highly efficient and low toxicity treatment and individualized treatment platform of the deep-buried tumors.

如何有效增强深部肿瘤组织对放疗射线的特异性，并降低对正常组织的损伤是临床放射治疗亟待解决的关键科学问题。针对该难题，申请人拟构建纳米脂质体金胶囊用于光热协同短距离放疗增敏胰腺癌治疗。该疗法中，纳米脂质体金胶囊同时作为光热剂与放疗增敏剂，通过静脉注射特异性靶向循环入胰腺癌组织；放射性碘125粒子作为短距离放射源植入肿瘤；近红外激光光纤穿过定制的空心PTC穿刺针进入腹腔，以提供微创光热疗所需光源。在近红外激光照射下，脂质体金胶囊既可将光能转化为热能杀死肿瘤细胞，又可通过激发-退激过程在瘤内产生次级带电粒子和辐射光子增强碘125粒子的有效放疗剂量，此外，光热作用有利于瓦解纳米脂质体金胶囊，保证其分解后的小尺寸组分顺利从肾脏排出，避免蓄积毒性。该疗法有望拓展深部组织肿瘤的高效低毒治疗和个体化治疗平台。

如何有效增强深部肿瘤组织对放疗射线的特异性，并降低对正常组织的损伤是临床放射治疗亟待解决的关键科学问题。针对该难题，申请人拟构建纳米脂质体金胶囊用于光热协同短距离放疗增敏胰腺癌治疗。该疗法中，纳米脂质体金胶囊同时作为光热剂与放疗增敏剂，通过静脉注射特异性靶向循环入胰腺癌组织；放射性碘125粒子作为短距离放射源植入肿瘤；近红外激光光纤穿过定制的空心PTC穿刺针进入腹腔，以提供微创光热疗所需光源。在近红外激光照射下，脂质体金胶囊既可将光能转化为热能杀死肿瘤细胞，又可通过激发-退激过程在瘤内产生次级带电粒子和辐射光子增强碘125粒子的有效放疗剂量，此外，光热作用有利于瓦解纳米脂质体金胶囊，保证其分解后的小尺寸组分顺利从肾脏排出，避免蓄积毒性。该疗法有望拓展深部组织肿瘤的高效低毒治疗和个体化治疗平台。