靶向NF-κB的圈套肽核酸对炎症介质生成的抑制作用研究
基本信息
结项摘要
根据目前在拮抗机体失控性炎症反应方面的不足，本研究以NF-κB圈套策略为突破口，设计圈套肽核酸以取代圈套寡聚脱氧核苷酸，从而有效解决后者易被核酸酶降解的难题；并通过其与NF-κB结合能力测定、对荧光素酶报道基因试验及炎症介质生成的影响、耐酶解及稳定性试验、体内抗炎效果验证，最终获得对NF-κB驱动的炎症反应具有高效拮抗作用的圈套肽核酸。
项目摘要
项目成果
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数据更新时间：2023-05-31
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