2型糖尿病股骨近端强度与骨折机制的数值模拟与多尺度实验研究

The incidence of type 2 diabetes mellitus (T2DM) is increasing rapidly. Osteoporotic hip fracture has been regarded as a serious complication of T2DM. However, radiography alone cannot clearly identify the mechanism of hip fracture to accurately identify the high-risk population. This project intends to establish a finite element analysis method based on the MRI image of patients with T2DM, and to get the evaluation of individual proximal femoral strength and related fracture risk, so as to identify the high-risk group. At the same time to establish a mouse model of T2DM, and the macroscopic mechanical properties and microscopic structure of morphology, micro-nano material properties and morphology, gene expression and other macro- micro-nano-genome multi-level property of the proximal femur changes. The hip fracture mechanism of T2DM is further explored. Finite element analysis and the results of animal experiments are integrated to determine bone morphology, density, material and other aspects of the role of the human body measurement for determining the T2DM proximal femoral strength. A series of independent parameters are put forward for clinical prediction of hip fracture load and fracture type and form. This project is expected to improve the accuracy of predicting the fracture risk of patients, and to play a guiding role for patients to choose a reasonable exercise to prevent fractures, which has important theoretical significance and practical value of clinical application.

2型糖尿病发病率呈快速增长趋势，髋部骨质疏松性骨折已被视为2型糖尿病的严重并发症，然而单纯放射线影像技术不能明确髋部骨折机制以准确鉴别高骨折风险人群。本项目拟建立基于临床2型糖尿病患者MRI影像的有限元分析方法，获得其个体化的股骨近端强度和相关骨折风险的评价，实现高骨折风险人群的鉴别。同时建立2型糖尿病小鼠模型，获得其股骨近端的宏观力学性能、细观结构形态、微纳观材料属性与组织形态、基因表达等宏观-细观-微纳观-基因组多尺度属性的变化，深入探索2型糖尿病髋部骨折机制。综合有限元分析与动物实验结果，确定对2型糖尿病股骨近端强度起决定作用的骨形态、密度、材料和人体测量等方面的重要指标，提出一系列独立的参数用于临床预测可能引起髋部骨折的载荷作用形式以及骨折的部位和类型，有望用于提高临床患者骨折风险预测的准确性，并为患者选择合理的锻炼方式以预防骨折起指导作用，具有重要的理论意义和临床实际应用价值。

2型糖尿病发病率呈快速增长趋势，髋部骨质疏松性骨折已被视为2型糖尿病的严重并发症，然而单纯放射线影像技术不能明确髋部骨折机制以准确鉴别高骨折风险人群。本项目拟建立基于临床2型糖尿病患者MRI影像的有限元分析方法，获得其个体化的股骨近端强度和相关骨折风险的评价，实现高骨折风险人群的鉴别。同时建立2型糖尿病小鼠模型，获得其股骨近端的宏观力学性能、细观结构形态、微纳观材料属性与组织形态、基因表达等宏观-细观-微纳观-基因组多尺度属性的变化，深入探索2型糖尿病髋部骨折机制。综合有限元分析与动物实验结果，确定对2型糖尿病股骨近端强度起决定作用的骨形态、密度、材料和人体测量等方面的重要指标，提出一系列独立的参数用于临床预测可能引起髋部骨折的载荷作用形式以及骨折的部位和类型，有望用于提高临床患者骨折风险预测的准确性，并为患者选择合理的锻炼方式以预防骨折起指导作用，具有重要的理论意义和临床实际应用价值。