便携式，可实时原位高度灵敏监测与区分苯类衍生物的智能传感器

BTEX (benzene, toluene, ethylbenzene and xylenes) have carcinogenic and mutagenic effects even at concentrations of a few parts per billion (ppb). Benzene is a well-known human carcinogen and can cause circulatory, immunological and neurological dysfunctions, while other BTEX compounds play a major role in ‘sick building syndrome’. Further, BTEX exist broadly in our environments, large quantities of BTEX are emitted into the atmosphere by the growth processes of plants, petroleum products, petrochemical industries, car exhaust, oil stoves, gardening products and automotive fuels stored in attached garages and basements, and materials used in car and building interiors, including paint, carpeting, leather and vinyl, and adhesives. This large number of BTEX sources coupled with their harmful impacts even at low levels, motivates the need for portable, high performance sensors. However, existing technologies suffer from many limitations: expensive, non-portable, off-site analysis, require challenging sample preparation, exhibit modest sensitivity, or need high operation temperature (~ 200 oC)...To overcome these limitations, we propose to develop a novel sensor platform based on a 2D orthogonal ambipolar semiconducting nanowire network that generates eight dimensional responses and provides portable and real-time detection of BTEX vapors with high sensitivity and discriminability, and to integrate these sensors into wireless signal transducer to enable simple smartphone-enabled readout. As proof of concept toward on-site applications, we will use this device to monitor the BTEX concentrations at various fields, including but not limit to gas station, inside vehicle, supermarket with plastic and rubber products, basement and area near chemical factory. We proposed that this study has the potential to provide new concepts in hazardous vapor sensing.

苯类衍生物是一类强致癌及基因诱变的有害物，即使在极低浓度下（ppb级别）也会损害人体健康。更为严重的是，苯类衍生物排放源头极其广泛，除了传统认知中的工业污染源（如石油石化生产）之外，还有更多意想不到的污染源存在于我们日常居住环境当中，这些污染源对我们的身体造成更为直接的伤害，比如：园林肥料，供暖设备，燃油炉灶，汽油柴油和汽车内饰等；如此广泛的苯类污染物排放源，加上其对人体的恶性致癌作用，使得我们迫切需要开发一类便携，高效灵敏的生化传感器。现有的苯类衍生物检测技术手段虽然具有灵敏度高，准确度好等优点，但其价格昂贵，检测耗时长，样品需要预处理，体积庞大，无法实现原位检测。为了填补这一技术空白，我们提出此研究项目，通过利用我们最近开发的新型的正交两性半导体器件，构建高性能的生化传感器。该类传感器件不仅可实现实时原位地高度灵敏地监测污染物，还便于携带，对实时保护人们的健康具有重要的意义。

大规模的工业生产使得经济得到高速发展的同时，也引起了严重的环境污染，特别是空气污染。其中苯类衍生物（包括苯，甲苯，乙基苯和二甲苯等）是空气污染物中最为危险的一类化学物质。即使在很低的浓度下（ppb级别），也会严重损害人们的健康。另外，苯类衍生物源分布极其广泛，在生活生产的方方面面都存在大量的潜在排放源。因此，迫切需要开发一类便携的，可实时原位检测苯类衍生物的，高效灵敏的生化传感器。而现有的苯类衍生物检测手段包含液相质谱联用仪等具有灵敏度高（ppb级别），准确度好等优点，但其价格昂贵，检测耗时较长，样品需要进行前期处理，体积庞大不可携带，无法实现原位检测，因此这些技术受众面非常窄，无法推广。发展便携式高灵敏度的生化传感器将有助于人们实时快速地评估空气质量，为人们的身体健康提供实时的保护，提高人们的生活质量；另外，有效检测并区分污染物中苯类衍生物的种类及各自的浓度将为空气污染的治理提供更具针对性的线索，为相关疾病的治疗提供更具指导性的依据。此外，该研究项目还将为开发新一代可穿戴的柔性生化传感器奠定技术基础。.为了填补这一技术空白，通过本项目的实施，我们利用正交两性半导体器件：1）制备及优化基于正交两性半导体的传感器，实现了对空气中甲苯、乙基苯、邻二甲苯、间二甲苯和对二甲苯高度灵敏（达ppb级别）且实时原位地检测；2）基于该类器件的八维信号响应，实现了检测并区分苯类衍生物的种类；此外，该类传感器还可对甲醇，乙醇，丙醇，丁醇和戊醇进行有效区分；识别精度达单个碳原子级别；3）发展了智能的器件读取技术，实现了便携功能。更为重要的是，通过发展神经形态器件，集成多个器件阵列，不但实现了高灵敏度和高选择性的气体检测，还实现了对气体源的快速精准定位，极大地拓宽了该类器件的应用范围。