新疆地区HIV-1分子流行病学及耐药突变的研究

AIDS has spread rapidly worldwide since its discovery, which has became one of the serious diseases endangering human health. At present, AIDS is described as “contemporary plague” and “super cancer”. No specific drugs and effective vaccines have been developed to treat and prevent AIDS because of the high variability and drug-resistance prevalence of HIV. AIDS is nationwide prevalance in China and Xinjiang is a high incidence. Though certain molecular epidemiological research was performed previously, new characteristics of AIDS spread occurred in Xinjiang, such as transmission by shared syringes in drug users was instead of sexual contact; homosexual transmission of AIDS from men to men increased speedly.So this study would to characterize current HIV-1 prevalance, gene variability and drug-resistant mutation of AIDS patients in Xinjiang, which would provide the molecular epidemiological basis for control,prevention, treatmentand vaccine development in this region.

艾滋病自发现以来迅速在全世界蔓延，已成为严重危害人类健康的疾病之一。由于HIV的高变异性及耐药性毒株的广泛流行，至今尚未研制出根治艾滋病的特效药物和有效预防的疫苗，因此艾滋病被称为“当代瘟疫”和“超级癌症”。中国是艾滋病流行大国，新疆维吾尔自治区又是我国艾滋病高发省份之一。尽管以往进行全国范围调查时已对本地区HIV-1分子流行病学进行了研究，但随着本地艾滋病传播呈现出了传播途径由性途径取代共用注射器吸毒，男男性接触人群感染人数快速上升的新特点，本研究拟结合本地艾滋病疫情现状及发展趋势，对当前新疆地区艾滋病感染人群中流行的HIV-1亚型、基因变异以及耐药突变进行研究，掌握最新动态，为HIV-1防控、治疗、疫苗的研制开发提供有力的分子流行病学依据。