基于多方法融合的无创血糖检测技术研究

The blood glucose level of diabetes patients needs be frequently measured, however the existing finger-tip blood test method may cause physical discomfort and infection risk. To solve this problem, we engage in the research of the metabolic heat conformation method and the impedance spectroscopy method, deeply and systematically, to explored multi-method fusion scheme to solve the key scientific and technological issues in non-invasive blood glucose monitoring. The main research contents include: 1) Studying the mechanism of metabolic heat conformation method, expounding the effect of insulin on metabolic heat conformation method, establishing a blood glucose calculation model which can be adapted to different environments and people; 2) Investigating the principle of impedance change caused by blood glucose changes, the method of extracting features, and estimating the blood glucose level combining the time series characteristics; 3) Compensating the effect of insulin in metabolic heat conformation method by using impedance spectroscopy, and compensating the changes of environmental and human tissue parameters in the impedance spectroscopy method by using the metabolic heat conformation method, improving the test accuracy through multi-method fusion; 4) Establishing self-testing network system and test methods through combining glucose clamp test, oral glucose tolerance test and patient self-test. Based on the research contents above, we expect to develop a daily-used noninvasive blood glucose monitor with high precision and good reliability, which is adapted to most of the population and wide operating conditions.

针对糖尿病患者需要频繁检测血糖，而指尖血检测方法会带来疼痛和感染威胁的现状，通过对代谢热整合法和阻抗谱法进行深入系统的研究，探索多方法融合的新方案，解决无创血糖检测中的关键科学和技术问题。主要研究内容包括：1）研究代谢热整合法的机理，阐明胰岛素对代谢热整合法的作用规律，建立适应不同环境和人群的血糖计算模型；2）研究血糖变化引起阻抗变化的原理和规律，研究提取特征值的方法，并结合时序特征进行血糖估计；3）利用阻抗谱法对代谢热整合法中胰岛素的作用进行补偿，利用代谢热整合法对阻抗谱法中环境和人体组织参数的变化进行补偿，通过多方法融合提高测试结果的准确性；4）将葡萄糖钳夹试验、口服葡萄糖耐量试验和患者自主测试试验相结合，建立自主测试试验网络系统和试验方法。基于以上研究内容，研制出适合日常使用的精度高、可靠性好、适应人群广、使用环境条件宽的无创血糖仪。

本项目将通过对代谢热整合法和阻抗谱法进行深入系统的研究，探索多方法融合无创血糖检测的新方案，研制出适合日常使用的精度高、可靠性好、适应人群广、使用环境条件宽的无创血糖仪。主要研究内容包括：1）研究人体散热量、血流量、血氧饱和度、血红蛋白浓度等生理参数的测量，胰岛素作用规律的研究，基于代谢热整合法的血糖计算模型建立方法；2）研究人体组织阻抗特性，及其随血糖浓度的变化，设计阻抗谱测试系统，进行特征量提取方法和血糖预测算法研究；3）研究阻抗谱法和代谢热整合法融合提高血糖测量准确度的算法框架和补偿机理，进行了毫米波无创血糖测试和基于一段时间内离散SMBG对HbA1c的最小化预测模型的研究；4）建立了临床试验所需的网络服务系统，进行了与OGTT做对比的无创糖尿病筛查试验和结合CGM与指尖血的临床试验研究。基于上述内容，完成多方法融合的无创血糖检测技术研究。