血管利钠肽防治慢性缺氧性右室肥厚的作用及机制

This work has studied the preventive and therapeutic effect of vasonatrin peptide (VNP) on the hypoxic right ventricular hypertrophy（HRVH）.Experiments in vivo suggested that VNP could significantly decrease right ventricular index ,average pulmonary artery pressure and pulmonary vascular resistance of HRVH rats. Effect of VNP was stronger than that of C-type natriuretic peptide(CNP) and atrial natriuretic peptide(ANP). Cell culture experiments suggested that VNP could inhibit the proliferation and collagen secretion of cardiac fibroblasts. VNP could also inhibit the hypertrophy of cardiac myocytes induced by moderate hypoxia. VNP had no effect on the survival rate of severe hypoxic cells but reduced the activity of lactate dehydrogenase. Molecular biology experiments suggested that VNP could reduce the level of NPR-C and ET-1 in hypoxic rat hearts and cultured cardiac myocytes. In conclusion , VNP is a strong anti-proliferation factor which can prevent and cure HRVH.

慢性缺氧引起右心室病变为主的心室泵功能下降和组织结构异常，实验研究血管利钠肽（VNP）对缺氧性右室肥厚的防治作用；VNP对离体心脏及离体冠脉的影响；探讨VNP对培养心肌赴⑿某上宋赴ぜ敖涸鞍缀铣傻囊种谱饔茫还鄄炻匀毖醴从χ蠽NP对ANP及其受寤虮泶锏牡骺亍Ｎ俅灿τ肰NP提供依据。