基于双通道激发光声技术的复杂血管光热响应的实时监测新方法

Vessels are channels both for tumor growth and metastasis and for the drug delivery in cancer treatment. Vessels play a crucial role in laser treatment of tumor. Thus, the project has important significance and application. We propose a dual-channel-irradiation photoacoustic method for simultaneous monitoring of tumor temperature, vessels morphology, and blood flow velocity during interstitial photothermal treatment of tumors based on the different characteristics of normal and tumor vascular structures. The contents of this project includes: multi-scale features of complex vessels; characteristics of photoacoustic spectroscopy of complex vessels under the condition of different photothermal temperature; vascular photothermal response based on interstitial photoacoustic temperature monitoring. There are innovations in this project including: a new model of photo-thermal response for multi-scale fractal vessels; the dual-channel-irradiation photoacoustic method and system; the imaging guided interstitial laser treatment of cancer using temperature monitoring and photoacoustic imaging of vessels. The dual-channel-irradiation photoacoustic imaging method will be developed for real-time monitoring of vessels during laser treatment of cancers, especially breast cancer, so as to realize the optimization of the treatment.

血管既是肿瘤生长和转移的通道，也是治疗肿瘤药物的通道。所以血管在肿瘤的激光治疗中的作用非常重要,开展此项研究具有重要的意义与应用价值。本项目基于正常和肿瘤血管的不同特征，发展一种双通道激发光声成像技术，在介入式光热治疗肿瘤中实时监测肿瘤温度分布和血管形态以及血流速度等变化。本申请项目拟开展以下研究：复杂血管的多尺度分布特征； 不同光热温度下复杂血管的光声光谱信号特征；介入式光声测温调控的复杂血管光热响应。创新点包括：建立多尺度分形血管光热响应模型; 构建双通道激发光声成像方法与系统; 开拓光声温度监控与血管光声成像导引相结合的介入式肿瘤光热疗法。本项目的预期目标是发展双通道激发光声成像监测新方法，在肿瘤特别是乳腺癌光热治疗过程中对血管进行实时监测，实现治疗方案的最优化。

血管既是肿瘤生长和转移的通道，也是治疗肿瘤药物的通道。所以血管在肿瘤的激光治疗中的作用非常重要。但是，肿瘤包括大血管和微血管，且血管的大小、密度、形态以及空间分布极其复杂，且周围组织和肿瘤的物理性质包括光学性质和热学性质参数多且与温度变化有关，因此，肿瘤光热治疗的精准治疗存在的核心困难。此项目采用双通道光声PID反馈控制技术在肿瘤光热治疗治疗同时监测组织光热温度与损伤特性，无须精确考虑光热治疗过程中肿瘤等组织物理性质及其对温度和损伤的影响，提高肿瘤治疗的效果。