药物与G-四股螺旋DNA相互作用的共振拉曼光谱和激光诱导的时间分辨荧光光谱研究
基本信息
结项摘要
以结构相对简单的平行四链、二聚发夹和单聚折叠的G-quadruplex DNAs为靶分子，以平面芳香型porphyrins化合物以及弯月型药物Distamycin和Berenil为模型化合物，利用激光诱导的时间分辨荧光光谱和激光共振拉曼光谱，并结合其它谱学方法如NMR，研究小分子药物与靶分子的相互作用。试图从分子生物学水平上回答药物对靶分子的键合模式、键合位点以及弱相互作用本质等关键问题，阐明结构
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数据更新时间：2023-05-31
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