甲基苯丙胺戒断者不同时期脉象脉图变化特点、发生机制及其与抑郁相关性的重复测量设计研究

Pulse diagnosis means a physician figuring out the body’s physiological and pathological changes by feeling the pulsation. According to TCM, the pulse may undergo corresponding physiological changes with influences of the internal and external factors. Methamphetamine (MA) is a common form of new drugs, which abused and addiction have become serious public health and social problems. The main cause of relapse is the withdrawal symptoms. And knowing these withdrawal symptoms and changes is significant. Mental symptom including depress is the most important performance. Pulse condition and tongue picture are the main performance in TCM. However, there is still no objective evidence about the pulse condition, changes and the relationship with mental symptom. This study will use methods of repeated measures design, choosing MA withdrawal people as the subjects to observe the changes of pulse condition, pulse graphs, depressing symptoms and BNP, cTn- T in blood at the day 7, 14and the end of 2,6 month. The study will explain the characteristics of the pulse condition and pulse graphs during different time points of MA withdrawal, then discuss the pulse mechanism from the perspective of the cardiovascular system. The study will provide objective evidence for the development of theory of pulse.

脉诊是指通过切脉，获取脉象，推断人体内部的生理、病理变化。根据中医理论，脉象受体内外因素的刺激而发生变化。甲基苯丙胺（俗称冰毒，英文简称MA）是一种常见的新型毒品，其滥用与成瘾已成为严重的公共卫生和社会问题。停用后出现的戒断症状是引起复吸的最主要因素。因此了解MA的戒断症状及变化特点具有重要的意义。包括抑郁在内的精神症状是MA戒断期最主要表现。中医方面，有研究报道主要表现为脉象改变。但MA戒断期脉象的表现特点、变化规律及其与精神症状的相关性如何，尚缺乏现代意义上的客观证据。本课题拟借助重复测量设计，连续、动态观测同一MA戒断人群戒断第7天，14天及第2、6月末的脉象、脉图、抑郁症状及血清BNP 和cTn- T，通过分析、比较以上指标及其变化，初步阐释MA戒断不同时点脉象、脉图的表现特点、变化规律及其与抑郁的相关性，并从心血管系统角度探讨脉象形成的原因，为促进中医脉诊理论的发展提供客观依据。