基于螺吡喃类小分子凝胶的多重手性逻辑门构筑

Molecular logic devices are the inevitable choice due to the limit of size from integrated circuits based silicon. The development of novel molecular logic devices has attracted more and more attention. To date, most molecular logic devices are confined to single output while few research on multiple output of molecular logic devices is presented. Moreover, the output signals are mostly focused on colorimetry, UV absorption, fluorescence and luminescence. The investigation of output from chiral CD and CPL signals is scarcely reported. Based on such conception, we will design and prepare two series of multiple chiral logic molecules, which are responsible to the stimuli from UV/vis, acid/base, metal ions or external chiral ligands. The logic molecules are composed of L-glutamate gelators conjugated by spiropyran derivatives, which contain the ligand, 2,2’- dipicolylamine. The chromophore group and L-glutamate moiety was separated by alkyl chains with different length. The goal gelator molecules have the properties of chirality, luminescence and coordination abilities. As a result, if the stimuli from UV/vis, acid/base, metal ions or external chiral ligands are served as chemical input, the corresponding UV absorption, fluorescence, CD and CPL signal will be obtained and used as output. Thus, the multiple chiral logic gate will be constructed. This simulation to chiral logic gate will provide the novel idea and method for the development of multiple chiral devices. Furthermore, such chiral logic gate will be applied for the encoded information, keypad lock and detection of chiral drugs.

分子逻辑器件是是现今硅基集成电路在尺寸方面的极限导致的必然选择。开发、设计新的分子逻辑器件目前已经引起科研人员的极大兴趣。迄今为止，大部分分子逻辑器件都局限于单一信号输出，多重输出信号的分子逻辑器件研究较少，并且输出信号基本上是比色、紫外吸收、荧光和发光等。而手性圆二色和圆偏振发光（CD和CPL）的输出逻辑门的设计和研究更加少见。基于此，本项目拟将配位能力较强且具备发光性能的双(2-吡啶基甲基)胺配体引入到螺吡喃分子中，以手性的L（D）谷氨酸十八酰胺为胶凝因子，合成得到两种系列对紫外可见光、酸碱、金属离子和外界手性配体响应的多重手性逻辑开关分子，以上述几种刺激作为化学输入（input），紫外吸收、荧光、CD和CPL作为输出（output），建立多重手性逻辑门，实现对目标逻辑功能的模拟，为多重手性逻辑器件的设计和制备提供新的思路和方法。并在此基础上实现在编码、锁键、手性药物检测等方面的应用。

基于布尔逻辑运算的分子逻辑门的设计是当前高度信息化现代社会发展的必然趋势和要求。而多重响应的有机分子设计和合成则为该理念提供了物质保证。相对于单一输出信号，多重信号输出势必会增加信息存储密度，为开发高容量分子器件提供新的思路和方法。本项目设计合成得到了两类含有机配体的手性螺吡喃凝胶剂小分子，一类含双(2-吡啶基甲基)胺配体，另一类含噻吩类配体。研究表明，该两类手性螺吡喃分子在大部分有机溶剂中形成凝胶体系。对紫外可见光、酸碱、金属离子等外部刺激多重响应。在这些外界因素的作用下，体系的紫外吸收，荧光，CD ，CPL信号甚至微观聚集态均发生可逆响应变化，由此，所得到的两类手性螺吡喃凝胶剂小分子都能成为多重手性逻辑开关分子。以紫外可见光、酸碱、金属离子外界刺激作为化学输入（input），紫外吸收、荧光、CD和CPL作为输出（output），建立多重手性逻辑门，实现了对目标逻辑功能的模拟，为多重手性逻辑器件的设计和制备提供新的思路和方法。