酶法制备高强度直链淀粉基水凝胶及其用于药物载体的研究

Hydrogels are widely used as the drug carrier due to their strength and softness, as well as their good biocompatibility, especially those degradable natural polymer-based ones. However, the poor mechanical strength of natural polymer-based hydrogels limited their application severely. In this project, we will synthesize amylose-based hydrogels with high strength and sustained-release function through the molecular design and will investigate on its structure and properties in depth. We will use straight chain maltodextrins as primers, and glucose 1-phosphate as substrates, four-armed polyethylene glycol as hydrogel matrix, and then drug-embedded amylose-based high-strength water hydrogel was synthesized using “enzymatic polymerization” preparation method. By designing uniform hydrogel network, the hydrogel strength can be greatly increased. Because the amylose synthesized is acid-resistant and can form complexes with hydrophobic drugs, the drug can be protected and slowly released from the amylose. Such amylose-based hydrogels with an excellent sustained-release performance and good physical and chemical properties will provide an important theoretical basis and application value.

水凝胶由于其既柔软又有强度，且有良好的生物相容性，尤其是可降解的天然高分子基水凝胶，被广泛用作药物载体。但是目前天然高分子基水凝胶存在着力学强度差的缺陷，严重限制了其应用。本课题通过分子设计和结构设计，合成具有高强度和缓释功能的直链淀粉基水凝胶，并且深入研究其结构和性能。将以直链麦芽多糖为引物，葡萄糖1-磷酸为底物，四臂聚乙二醇为凝胶骨架，采用“酶促聚合法”制备药物包埋型直链淀粉基高强度水凝胶，通过精巧的设计使凝胶网络均一，从而大大提高了凝胶的强度。由于直链淀粉具有耐胃酸水解以及可与疏水药物形成络合物的特性，水凝胶被赋予了缓释和保护药物的性能。本课题可为构建具有优良缓释效果和理化特性的淀粉基水凝胶药物载体提供重要理论依据和应用潜力。

水凝胶由于其既柔软又有强度，且有良好的生物相容性，尤其是可降解的天然高分子基水凝胶，被广泛用作药物载体。但是目前天然高分子基水凝胶存在着力学强度差的缺陷，严重限制了其应用。本课题通过分子设计和结构设计，合成具有高强度和缓释功能的直链淀粉基水凝胶，并且深入研究其结构和性能。将以直链麦芽多糖为引物，葡萄糖1-磷酸为底物，四臂聚乙二醇为凝胶骨架，采用“酶促聚合法”制备药物包埋型直链淀粉基高强度水凝胶，通过精巧的设计使凝胶网络均一，从而大大提高了凝胶的强度。本项目成功的进行了直链淀粉的体外酶促合成，并对所得淀粉性质进行了表征。在此基础上，按照实验方案将直链淀粉制备成了水凝胶，并对其水凝胶性质和行为进行了评价。不幸的是，该材料并未展示出预计的良好性能。因此，我们做了基于间氨基苯硼酸、聚苯胺和聚乙烯醇的高分子碳气凝胶，对其性能做了表征，并在生物电化学应用上做了探索。