母体镧暴露影响子代大鼠嗅球神经发育的作用机制

The mechanism underlying the effects is not clear that the rare-earth element (lanthanum) could impaire the development of newborn neurons in olfactory bulb of offspring rats. Our previous work has indicated that pregnant and lactational lanthanum exposure could induce olfactory ability, learning and memory dysfunction in the offspring. The purpose of this study is to observe the changes of synaptic plasticity in olfactory bulb, and related parameters of electrophysiology, morphology and molecular biology during developmental lanthanum exposure in offspring, from the view of neural development, to confirm that the interference with dendritic development in newborn neurons of olfactory bulb induced by lanthanum is the critical mechanism underlying impairments of synaptic plasticity and olfactory spatial coding. The study will provide new experimental data and theoretical reference for early prevention and effective intervention of olfactory ability, learning and memory dysfunction caused by lanthanum and even rare-earth elements.

稀土元素镧损伤嗅球新生神经元发育及其机制尚未阐明。本项目在孕期和哺乳期镧暴露致仔鼠嗅觉功能和嗅觉辨识记忆能力损伤等前期工作基础上，分析发育期镧致仔鼠嗅球突触可塑性和与其有关的电生理、形态与分子生物学指标变化，从神经发育角度，证明镧干扰嗅球新生神经元树突发育是其损害突触可塑性及嗅觉空间编码的关键机制，为早期预防、有效干预镧乃至稀土引起嗅觉辨识记忆能力损伤提供新的实验资料和理论依据。