髓系来源的抑制性细胞在肝炎期肝脏修复中的作用及其机制研究

A group of immature myeloid-derived suppressor cells (MDSCs) was observed to play opposing roles In the process of hepatic fibrosis. In response to liver injury, MDSCs induced liver fibrosis by secreting proinflammatory factors, which also alleviated liver fibrosis by anti-inflammatory factors in the meantime. In our previous studies, we observed not only increasing synthesis of extracellular matrix components, but also activating liver cell proliferation in the liver mass, which was under the influence of MDSCs. However, roles of MDSCs in promoting liver cell proliferation upon chronic hepatitis and its underling mechanisms have not been addressed. We conjecture liver cell proliferation is effected by MDSCs directly or indirectly. This subject will focus on investigating the role of MDSCs especially to liver cells and its underling mechanisms in the process of hepatic fibrosis, which will further clarify the roles and mechanisms of MDSCs in liver regeneration in the stage of liver inflammation, provide new ideas and theoretical basis for preventing and treating hepatic fibrosis.

在肝炎导致的肝纤维化过程中，骨髓来源的抑制性细胞(Myeloid-derived suppressor cell, MDSC)起到了多重作用，他可以通过分泌促炎因子诱导肝脏发生纤维化；同时又可以分泌抑制炎症的因子缓解肝脏纤维化的发生。我们在前期研究中发现，肝脏在损伤早期既有大量骨髓来源的MDSC细胞动员至肝脏；MDSC作用的肝脏组织块，不仅肝脏间质增生活跃，肝细胞的增殖也很活跃，但MDSC促进肝细胞增值的有关机制尚不清楚。我们推测MDSC直接或间接的对肝脏细胞的增值起到一定的作用。本课题重点研究MDSC在肝脏炎症导致的肝纤维化过程中的作用，尤其是对肝脏细胞的作用，并探讨MDSC对肝脏细胞作用的机制，阐明MDSC在肝脏炎症期肝脏修复中的作用及其机制，为肝脏炎症和纤维化发生及其预防、治疗提供新的基础和思路。