母体高脂肪饮食对雌性子代的代谢及卵巢功能的影响

Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism ,polycystic ovaries and anovulation along with insulin resistencs, obdominal obesity metabolic traits. Due to these heterogeneity ,the early pathophysiological mechanisms unclear. however，Clinical ,experimental and genetic evidence believed potential role fetal programming in the pathogenesis of PCOS phenotype in adult life . At present researchs are mainly based on infertility in PCOS reproductive age women, lack of attention to adolescent patients. Second, study of the intrauterine environment pathogenic role is less. Our objective is to know whether maternal high fat diet exposure to metabolic and reproductive derangements of PCOS in pubertal female rat. To provide etiological basis for the occurrence of PCOS.

多囊卵巢综合征(polycystic ovary syndrome, PCOS) 因其涉及下丘脑、垂体、卵巢、肾上腺、胰腺及遗传等诸多因素,发病机制、生化改变及临床表现有高度异质性,确切病因尚未阐明。最近研究发现：发现维吾尔族患者组其母体体重指数超标，体内具有高雄激素或有高雄激素的临床表现者,后代更容易患PCOS，表现出肥胖，不孕及高雄激素血症。目前国内PCOS的研究存在以下问题，第一，研究主要基于不孕门诊的育龄期女性，对青春期患者关注不足。第二，由于缺乏准确的检测方法，使宫内环境因素致病作用的研究少。我们的前期研究发现雄性子代受母体高热量进食的暴露可能造成青春期葡萄糖刺激胰岛素分泌不足。根据此发现，本课题组提出假设发育中的雌性子代受母体高热量进食的暴露可能造成青春期糖脂代谢及卵巢生殖功能紊乱。本项目欲通过建立高热量膳食的动物模型，研究雌性子代的代谢及生殖特征，寻找是否与人类PＣＯＳ的发病有潜在相关性，为ＰＣＯＳ的发病提供病因学依据.