用于脑出血检测的微波热声成像技术研究

The goal of this project is to develop a new noninvasive imaging technology for rapid and high fidelity detection of hemorrhagic stroke. There is an urgent unmet clinical need for a noninvasive and fast imaging technology that can rapidly distinguish between ischemic and hemorrhagic stroke. We hypothesize that microwave induced thermoacoustic imaging (TAI) can satisfy this need. In this project, we will build a fast data collection platform through flexible ultrasonic array and multi-channel data acquisition system. We will also develop a delay and sum reconstruction algorithm for the flexible bending of the arbitrarily curved shape of the array. The algorithm is combined with a fiber optic shape sensing device which measures the position of the elements along the array. Finally, we will test and evaluate this technology for detection of hemorrhagic stroke in phantom, rhesus models and normal human. Upon successful completion of this project, this research will provide a powerful new diagnostic imaging technology for rapid detection of hemorrhagic stroke. This innovative technology will significantly reduce the mortality rate, disability rate, morbidity and recurrence rate associated with stroke, and improve the stroke prevention in China and in the world.

为满足临床中对快速鉴别脑出血和脑缺血的重大需求，本项目拟开展用于脑出血检测的微波热声成像技术研究，为快速检测脑出血提供一种崭新的影像技术。本项目拟通过柔性超声阵列探头和多通道数据采集系统构建快速数据获取平台；基于光纤光栅形状传感技术，获取柔性超声阵列探头晶元二维位置信息，开发适用于柔性超声阵列探头任意弯曲形状的延迟叠加图像重建算法；并利用仿体、脑出血恒河猴模型和正常人体实验对该技术性能进行评估，为该技术临床实验的开展奠定基础。通过本项目开展的脑出血微波热声成像检测技术研究，可高分辨率、高灵敏度的无损检测脑出血，并对出血灶大小和位置进行二维可视化。该技术通过对脑出血的快速检测，可提高缺血性卒中患者溶栓率及康复率，降低患者死亡率和致残率；还可通过定期筛查和复查，降低卒中发病率和复发率，有助于提升我国在脑卒中防治领域的综合实力和国际影响力，具有重大的科学价值和实用意义。

本项目基于临床中对快速鉴别脑出血和脑缺血的重大需求，开展了用于脑出血检测的微波热声成像技术研究。本项目首先完成了基于柔性超声阵列探头的多通道热声脑出血成像实验系统构建；同时，开发出了针对柔性超声阵列探头分布不均匀进行修正的延迟叠加算法；最后，基于脑出血仿体、正常人手臂血管和人脑热声成像完成了用于脑出血热声成像技术的性能评估。通过本项目开展的脑出血微波热声成像检测技术研究，可高分辨率(0.9 mm)、快速(<2 s)无损检测脑出血，并对出血灶大小和位置进行二维可视化。该技术为快速检测脑出血提供了一种崭新的影像技术，可提高缺血性卒中患者溶栓率及康复率，降低患者死亡率和致残率；还可通过定期筛查和复查，降低卒中发病率和复发率，有助于提升我国在脑卒中防治领域的综合实力和国际影响力，具有重大的科学价值和实用意义。