烷基取代二肽和三肽螺旋自组装行为及在螺旋共价有机骨架材料纳米管制备中的应用

This project aims at studying the self-assembly behavior of alkyl substituted dipeptides and tripepetides and preparing chiral covalent organic framework nanotubes through a supramolecular-templating method. Firstly, alkyl substituted dipeptides and tripepetides will be synthesized. Their self-assembly behavior will be controlled by tuning the kinds and chirality of the amino acids. The structures and optical activity of the supramolecular self-assemblies, handedness reversals and spontaneous resolution will be investigated using infrared spectroscopy, ultraviolet spectroscopy, X-ray diffraction, and circular dichroism. Secondly, single-handed helical covalent organic framework nanotubes will be prepared using the self-assemblies of the dipeptides and tripeptides as the templates. The helical structures of the nanotubes will be controlled by adjusting the reaction conditions and the molecular structures of the supramolecular self-assemblies. Meanwhile, the origin of the optical activity of the nanotubes will be studied using CD, scanning and transmission electron microscopies. Finally, the nanotubes and their derivatives will be applied in the fields of enantioseparation,electromagnetic wave absorption and supercapacitor.

本项目旨在研究烷基取代二肽和三肽的超分子自组装行为，并以其自组装体为模板法制备共价有机骨架材料纳米管。首先，合成烷基取代二肽和三肽化合物。通过调整氨基酸种类和手性控制其自组装行为，并运用红外、X-射线衍射、圆二色谱以及漫反射圆二色谱法研究超分子自组装体的结构及手性节和自发拆分形成的机理。然后，以二肽和三肽的超分子自组装体为模板制备单手螺旋共价有机框架材料纳米管。通过改变超分子自组装体的结构控制共价有机骨架材料纳米管的结构，并利用圆二色谱、扫描和透射电镜对产物的光学活性的来源进行深入解析。最后，研究所得手性共价有机骨架材料纳米管和其衍生物在对映体分离、电磁波吸收以及超级电容器等领域的应用。

本项目旨在研究烷基取代二肽和三肽的超分子自组装行为，并以其自组装体为模板法制备共价有机框架材料和有机-无机氧化硅。首先，合成了烷基取代二肽和三肽化合物。通过调整氨基酸种类和手性控制其自组装行为，并运用红外、X-射线衍射、圆二色谱以及漫反射圆二色谱法研究了超分子自组装体的结构与其手性的关系。然后，以二肽和三肽的超分子自组装体为模板制备单手螺旋共价有机框架材料和有机-无机杂化氧化硅。通过改变超分子自组装体的结构控制共价有机框架材料和有机-无机杂化氧化硅的结构，并利用圆二色谱、扫描和透射电镜对产物的光学活性的来源进行深入解析。最后，研究所得手性材料和其衍生物在圆偏振光发射以及对映体分离等领域的应用。