基于自旋交叉的手性分子探针的定向构筑与研究

In the various methods of chiral recognition, chiral sensor has attracted tremendous attention for its detection speed and high sensitivity. With the development of biological science and materials chemistry, it put forward higher requirements for the designing and development of chiral sensors. Considering that the spin crossover (SCO) complexes are spin-sensitive to the various guest molecules, this project aims to construct new magnetic switch chemical sensor with chiral recognition function that based on excellent classical SCO system. Compared with traditional non-magnetic chemical sensors, the magnetic switch chemical sensor has much stronger and more sensitive signal response, and has the advantages of simultaneous output of light, electricity and magnetism. Aiming at the construction and modulation of chiral sensors that based on SCO behavior, we choose 1) iron-triazole chain system and/or 2) using chiral bi-pyridine ligands to build 2D or 3D microporous polymers to get the chiral spin crossover frameworks. Their spin crossover behavior, magnetic-chiral interaction will be studied as the introduction of chiral object. It will provide new ideas for exploring effective and sensitive chiral sensors with multiple response channels.

在手性识别的各种方法中，手性传感器具有简单快捷、灵敏度高的特点，近些年受到格外关注，而随着生命科学和材料化学的迅速发展，对手性传感器的设计和开发提出了更高的要求。本项目拟在已有工作基础的积累上，从自旋交叉配合物对客体的敏感性出发，以经典的自旋交叉体系为切入点，设计具有手性识别功能的新型磁开关传感器。与无磁性变化的化学传感器相比，自旋交叉化学传感器有着更强更灵敏的信号响应，具备可同时输出可开关的光、电、磁等多种信号变化的优点。本项目针对手性分子化学传感器的科学问题，选取1）二价铁三氮唑一维链体系后合成手性一维链和2）利用手性双吡啶类配体定向构筑二维或三维微孔聚合物，得到手性自旋交叉框架。在框架内引入不同的手性客体或者手性阴离子对映体，系统考察材料的光电磁等方面性质变化，最终得到对手性对映体的特异性识别的自旋交叉材料，为探索具有多响应通道，高效灵敏的手性传感器提供新的理论依据和实验支持。

具有分子识别功能的材料是多功能配合物材料中一个研究热点。近年来，越来越多的研究者开始探究其在化学传感器、磁共振成像和多功能分子开关器件方面的潜在应用。本研究旨在开发具有识别功能的多功能配合物材料以应用于化学传感器，主要包括以下方面：1. 化银钾构筑了hoffman型多孔框架，进行主客体作用小分子识别研究；2.构筑Ag荧光配合物，进行小分子识别；3.构筑两例Cu配合物，并研究了其与生物体内DNA上位点的特异性作用；4. 结构与性能之间的相关性，为设计高选择性和高灵敏度的多功能化学传感器提供思路。