基于LSPR效应的新型磁-光双模态成像材料设计合成及性能调控研究

The advance in highly performance bimodal imaging material is a key scientific challenge in the precise treatment of tumors. In order to overcome the drawbacks of currently available magnetic-luminescent bimodal imaging materials in terms of low sensitivity and inferior penetration depth, this project aims to construct a novel Fe3O4@(Mo,W)O3-x(x=0~1)@(Y,Gd)F3:RE3+(Eu,Tb,Er/Yb)magnetic-luminescent bimodal imaging material with improved sensitivity and penetration depth towards imaging in vivo, which contribute to the synergetic optimization of magnetic and luminescent via introducing layers with localized surface plasmon resonance (LSPR) effect. The interaction mechanism of the interface, evolution law of surface states, coating model and controllable synthesis will be clarified. Influence and strenthening mechanism of the oxide layer on magnetic and luminescence properties will be thoroughly investigated, and effective regulation of surface structure and properties of the material will be realized by design of reaction conditions. The cell imaging effect in vitro of imaging materials will be disclosed, in order to construct a new type of bimodal probe with high-performance. This research conclusion can solve the property problems of the magnetic-luminescent of bimodal imaging material and promote imaging material applications in tumor diagnosis, therapy, and optical confocal microscopy technology.

开发高性能磁-光双模态成像材料是肿瘤精准治疗领域的关键科学问题之一。针对现有磁-光双模态成像材料灵敏度低与穿透深度不足的缺陷，本项目提出通过引入局域表面等离子体共振（LSPR）效应的隔层，优化磁性与发光性，改善成像灵敏度和穿透深度，构筑新型Fe3O4@(Mo,W)O3-x(x=0~1)@(Y,Gd)F3:RE3+(Eu,Tb,Yb/Er) 磁-光双模态成像材料。揭示其界面作用机理及表面态的演变规律，建立包覆模型，实现新型磁-光双模态成像材料的可控合成。深入研究氧化物隔层对其磁性和发光性能的影响与增强作用机理，通过反应条件的设计，实现该材料表面结构及物性的有效调控。开展该材料的生物实验研究，揭示其体外细胞成像效果，以期构建高性能磁-光双模态探针。该工作将解决磁-光双模态成像材料性能方面的瓶颈问题，为推进该类材料在肿瘤精准诊疗和光学共聚焦显微技术中的应用提供理论依据和实验基础。

高性能磁-光双模态成像材料是实现肿瘤精准治疗的关键探针材料。现有磁-光双模态成像材料的灵敏度与穿透深度仍不能满足医用要求。本项目通过引入局域表面等离子体共振（LSPR）效应的隔层的方法，优化磁-光双模态成像材料的磁性与发光性，从而改善成像灵敏度和穿透深度，构筑了新型Fe3O4@(Mo,W)O3x(x=0~1)@(Y,Gd)F3:RE3+.(Eu,Tb,Yb/Er) 磁-光双模态成像材料。分析研究了其界面作用机理及表面态的演变规律，实现了新型磁-光双模态成像材料的可控合成。深入探讨了氧化物隔层对其磁性和发光性能的影响与增强作用机理，开展了部分体外细胞成像研究。该工作将解决磁-光双模态成像材料性能方面的瓶颈问题，为推进该类材料在肿瘤精准诊疗和光学共聚焦显微技术中的应用提供理论依据和实验基础。