特殊环境（南极）对机体行为改变的内分泌机制及防治

Due to its extreme environment, not only geophysical but also metaphysical isolation, there are both physiological and psychological stressors that the expeditors have to be faced with in Antarctica. It was reported that western people who had lived and worked in Antarctica for more than four to five months developed a characteristic constellation of symptoms and thyroid hormone changes called the Polar T3 syndrome.. Considering different race, society and cultural background, maybe the physiological and psychological changes are different between Chinese and the western expeditions..China constructed the Greet Wall Station, up to now 19 teams had been dispatched to conduct scientific investigation there. Since then, a series of human physiological and psychological changes were found during the expedition members staying and working in Antarctic Great Wall Station and Zhong Shan Station. These changes include temporary declines of cardiac and immune function and flexibility of higher nervous system activity .Changes in personal character and psychological behaviours of some Chinese expedition members were also found, especially in winter. These included emotional instability with anxiety, depression, and sleep disturbances. An increase in desynchronization of electroencephalogram readings suggested stress on higher nervous system function . This increase was accompanied by changes in endocrine function, which might play an important role in the physiological adaptation to the harsh polar environment. Our previous results showed that plasma cortisol and urinary adrenaline and noradrenaline were increased, but no data of plasma catecholamine were obtained Serum thyroid hormones, plasma catecholamines and mood were examined in 10 male members of the 16th and 17th Chinese Antarctic Expedition. Samples were taken prior to deployment to Antarctica (December, 1999) and upon return to China 54 weeks later (December, 2000). There was a significant decrease in levels of TT4 (P<0.01) and E (P < 0.05), and a significant increase in TSH (P<0.01). The expeditioners were also asked to complete the Profile of Mood States (POMS) each month over an 8-month period (April through November, 2000). With the exception of a significant decline in level of vigor (p=0.008), there were no significant changes in mood throughout the expedition. Low levels of pre- and post-deployment Total T3 and high levels of TSH were significantly associated with high levels of tension-anxiety, depression, anger, confusion, and total mood disturbance at the beginning and end of winter. High levels of TSH were also significantly associated with high levels of fatigue (p < 0.001), while low levels of total T4 were significantly associated with high levels of tension-anxiety (p < 0.001), depression (p < 0.05), and total mood disturbance (p < 0.05). Low levels of dopamine were significantly associated with high levels of tension-anxiety (p < 0.05). Meanwhile, increase in anger with significantly associated with an increase in adrenalin (p < 0.05). The results provide partial support for the Polar T3 Hypothesis and suggest that long-term adaptation to the extreme and isolated Antarctic environment involves changes in the regulation of mood and metabolism that give rise to a new psychophysiological homeostasis..

观察2000－2001年居留南极考察队员的心理行为、血中甲状腺素和肾上腺髓质神经体液内分泌的变化，同时复制慢性社会应激大鼠模型，用多种行为学方法测试行为/性格，并检测血湍浴⒛诜置诘茸橹猩鲜鎏逡阂蜃雍湍诜置诩に兀教痔厥馍缁峄肪扯曰逍形谋涞纳窬诜置诘鹘诨疲捎肔-甲状腺素替代等措施，纠正下丘脑-垂体-靶腺轴的反馈调节紊乱乐涡睦肀浠胄睦碚习霸缃饩鲈蕉酆现⒍钥疾於釉钡奈：Α