血管支架的流固耦合血流动力学模型机理和实验研究

Principle Investigator's previous work focuses on the optimization design of vascular stent structure, nonlinear finite element analysis of expansion and measurement of experiments. This research will start with studying the current status of art of the mechanical behavior and experimental instrument designs of stent. Then, this research will study the mechanical behavior optimization and measurement approaches of the stent coupling system. A compositive research strategy is available to study and manufacture the vascular stent with excellent mechanical properties. And practical compositive property level can be achieved. Specifically, ①Vascular, atherosclerotic plaque, stent and blood are regarded as a fluid-structure interaction(FSI) system. The FSI equation and numerical simulation of coupling system are studied to provide a theory basis for designing vascular stent with excellent properties. ②An numerical model that describes the hemodynamics of vascular, stent and blood coupling system before and after the interposition process is established and solved. Optimization model of mechanical behaviors in the hemodynamics based on multi-objective optimization strategy is established and relative solution and analysis tool is supplied. ③A measurement equipment of vascular stent mechanical properties is exploited. Thus, mechanical properties of hemodynamics before and after stent implantation can be measured and analyzed accurately.

基于申请者前期在医用血管支架的结构优化设计、扩张过程非线性有限元分析以及实验测试等方面的前期工作基础，综合比较国内外血管支架力学性能分析的理论和实验成果，开展医用血管支架介入耦合系统力学行为优化与测试方法研究，将基础理论研究和测试装置研制有机结合，为高性能血管支架的研制提供一个综合性的研究思路，并达到实用化的综合性能指标水平。具体而言：①将血管壁、硬化斑块、支架和血液作为一个流固耦合系统，研究描述该系统的力学性质基本理论和数值模拟方法，为设计高性能的医用血管支架提供理论基础；②研究建立描述血管支架植入前后的血流动力学性能的流固耦合模型，建立基于血流动力学的力学行为优化模型，并提供相应的求解分析工具；③研究开发血管支架力学性能测试装置，实现对支架植入前后涉及的血流动力学性能的精确测量与分析。

基于申请者前期在医用血管支架的结构优化设计、扩张过程非线性有限元分析以及实验测试等方面的前期工作基础，综合比较国内外血管支架力学性能分析的理论和实验成果，开展医用血管支架介入耦合系统力学行为优化与测试方法研究，将基础理论研究和测试装置研制有机结合，为高性能血管支架的研制提供一个综合性的研究思路，并达到实用化的综合性能指标水平。具体而言：①将血管壁、硬化斑块、支架和血液作为一个流固耦合系统，研究描述该系统的力学性质基本理论和数值模拟方法，为设计高性能的医用血管支架提供理论基础；②研究建立描述血管支架植入前后的血流动力学性能的流固耦合模型，建立基于血流动力学的力学行为优化模型，并提供相应的求解分析工具；③研究开发血管支架力学性能测试装置，实现对支架植入前后涉及的血流动力学性能的精确测量与分析。