指导专家组调研和组织学术交流会费用

Nonresolving inflammation is a major driver of disease. Perpetuation of inflammation is an inherent risk because inflammation can damage tissue and necrosis can provoke inflammation. Nonetheless, multiple mechanisms normally ensure resolution. Cells like macrophages switch phenotypes, secreted molecules like reactive oxygen intermediates switch impact from pro- to anti-inflammatory, and additional mediators of resolution arise, including proteins, lipids, and gasses. Aside from persistence of initiating stimuli, nonresolution may result from deficiencies in these mechanisms when an inflammatory response begins either excessively or subnormally. Further, nonresolving inflammation is also a component of the tumor microenvironment. The linkage between inflammation and cancer, first perceived in the nineteenth century, is now part of an accepted paradigm of carcinogenesis. Here, our project plans to support inflammation-related academic exchanges and the funding of consultant for expert group.

炎症是宿主系统对病原体感染等产生的一系列复杂的动态变化事件，他们通过影响微环境中多种细胞与多种因子的相互作用，调控机体生理与病理信号网络的平衡状态。基金委医学部前期针对国家发展规划纲要中提出的“重点研究生理和病理过程中关键基因功能及其调控网络的规模化识别”的需求，从系统生物学的宏观角度出发，提出以炎症与肿瘤的调控网络及分子机制为核心内涵，发现、整合、归纳炎症调控网络中影响肿瘤发生发展的关键节点（群），阐明关键节点在网络中定位及对网络动力学的调控方式；界定非可控性（nonresolving）炎症的潜在诱发因素；剖析关键分子调控可控性（resolving）与非可控性（nonresolving）炎症之间平衡走向的内在机制；发展和建立基于系统生物学的研究炎症与肿瘤调控网络的新理论、新策略和新方法等若干研究方向。此次专家组将在项目经费的支持下进行广泛研讨和调研，并对项目中后期集成研究提出合理方案。