基于柱芳烃的荧光功能材料

As one of the novel functional materials, fluorescent emissive materials are of great importance to our daily life, industrial and agricultural production, and the development of chemistry, biology, medicine, electronics and biology. It becomes one of the most potential and challenging research topics in current society in terms of developing novel solid-state fluorescent materials with good stability, efficient fluorescent emission and stimuli-responsibility. In this proposal, we aim to synthesize a series of fluorescent pillar[n]arene derivatives and their corresponding guest molecules with aggregation-induced emission and fluorescence enhancement properties. Taking advantage of the special supramolecular host-guest properties of pillararenes - a new generation of supramolecular macrocycles - blue and yellow or red fluorophores can be combined together to result in FRET effect governed by supramolecular self-assembly. Finally, the supramolecular fluorescent gels with stimuli-responsibility and self-healing properties, pillararene-stabilized rear-earth upconverting nano-hybrid materials, and self-probing and targeting hybrid controlled delivery system will be constructed and studied, employing the host-guest supramolecular interactions and self-assembly induced fluorescent emission and FRET mechanisms. These pillararene-based new supramolecular fluorescent nano-hybrid materials will be applied to the detection of trace analytes, medical analysis, monitoring of controlled drug delivery, and targeted cancer diagnostics and therapy.

荧光发光材料作为一类新型功能材料对人类日常生活和工农业生产以及化学、生物、医学、电子和生命科学等领域的发展都有着重要意义。构筑稳定性好、发光效率高且对外界环境具有刺激响应性的新型固态荧光功能材料已成为当今科学领域最具潜力和挑战的研究热点之一。本项目拟合成一系列具有聚集诱导发光或荧光增强等特性的功能柱芳烃衍生物及其特征识别的客体分子，利用新一代超分子大环柱芳烃独特的超分子主客体性质，将蓝光生色团与黄光、红光生色团聚集，实现超分子自组装驱动的荧光共振能量转移（FRET）发光机制；主客体超分子作用与自组装诱导的荧光增强和FRET机制将被用于具有刺激响应性和自修复性的超分子荧光凝胶、柱芳烃稳定的稀土上转换纳米粒子复合材料和靶向自身探针型复合纳米释药材料的构筑及性能研究。这些基于柱芳烃的新型超分子荧光纳米复合材料将被应用于痕量检测、药物分析、药物释放监测和靶向型癌病诊疗。

荧光发光材料作为一类新型功能材料对人类日常生活和工农业生产以及化学、生物、医学、电子和生命科学等领域的发展都有着重要意义。构筑稳定性好、发光效率高且对外界环境具有刺激响应性的新型固态荧光功能材料已成为当今科学领域最具潜力和挑战的研究热点之一。通过本项目的实施，我们合成了一系列具有聚集诱导发光或荧光增强等特性的功能柱芳烃衍生物及其特征识别的客体分子，并利用新一代超分子大环柱芳烃独特的超分子主客体性质，将蓝光生色团与黄光、红光生色团聚集，实现超分子自组装驱动的荧光共振能量转移（FRET）发光机制；随后，我们将主客体超分子作用与自组装诱导的荧光增强和FRET机制用于具有刺激响应性等特性的超分子荧光凝胶、柱芳烃稳定的稀土上转换纳米粒子和碳点复合材料、靶向自身探针型复合纳米释药材料等的构筑及性能研究。探索了这些基于柱芳烃的新型超分子荧光纳米复合材料在传感检测、发光材料、药物释放监测、细胞成像、靶向型癌病诊疗等方面的潜在应用，并为其提供了重要的技术和理论支撑。相关重要结果已在National Science Review, Advanced Materials, Journal of the American Chemical Society, Angewandte Chemie International Edition, Matter, Research, Theranostics等重要期刊发表该基金标注论文60篇（通讯作者论文59篇），获授权发明专利1项。研究工作多次被选为杂志封面和内封面，并被Advanced Science News, Materials Views China等多次正面报道。项目负责人入选科睿唯安全球高被引科学家、爱思唯尔中国高被引学者、英国皇家化学会高分子化学领军科学家等。科研成果获吉林省自然科学一等奖和天津市自然科学二等奖。