血管性介入治疗中的血流动力学问题研究

Based on anatomical and physiological character of the target blood vessel, we set up a high simulation analog equipment of interventional therapy for lung cancer by means of Cardiovascular hemodynamics fundamental and method, and measure the parameters of the pressure and flux of experimental model; complete automation of injection time-phase, volume of drug injected from injection syringe, rate of drug entering into branch vessels from Aorta and positions of entrance of drug injected into Aorta; complete morphological image acquisition and image processing of drug flowing through the blood vessels; erect the mathematical model and numerical calculation of the distribution of flow field. Carry through simulation experiments in vitro and numerical analysis and treatment; propose PH-value method and Ion radical method that can solve the problem about the calculation of the perfusion rate of drug successfully; study the Factors affecting the natural infusion region in many different cases through experiments; explain the theory of complications caused by interventional therapy. Partial experimental techniques can be applied in clinic to enhance effect of treatment and to reduce the ill effect of treatment. These innovative researches have not only theoretical meaning but also clinical application va

应用血管入口流动理论，依据靶血管的解剖学、生理学特点，建立靶血管流场状态的数学模型，进行介入治疗过程中及治疗后的血管流场分析，阐明介入治疗过程的血流动力学机理，并为解决介入治疗过程和介入治疗后产生的并发症问题提供有效的原理和依据。这将对我国及世界的介入放射学的发展起重大的推动作用，具有重大的科学意义和应用价值。