丘脑参与持续性痛觉调制与针刺镇痛的递质与受体机制

The present study has demonstrated that opioid peptide, 5-hydroxytryptamine (5-HT),.glutamate and gamma-aminobutyric acid (GABA) and their receptors were involved in the.thalamic nucleus submedius (Sm)-mediated antinociception, and support our provided.hypothesis that the Sm opioid- or 5-HT-induced antinociception may be produced by.inhibition of a GABAergic interneuron which inhibits the output neuron projecting to the.ventrolateral orbital cortex (VLO) (a desinhibitory effect), leading to activation of the.VLO-PAG-brainstem descending inhibitory system and depression of the nociceptive inputs.at the spinal level; the excitatory neurotransmitter glutamate may directly activate this.antinociceptive pathway via the non-NMDA receptors, while the GABA may tonically inhibit.the activity of this pathway. These results provide important evidence for the neurotransmitter.and receptor mechanisms involved the forebrain and thalamus in nociceptive modulation in.which 19 articles have been published. Of them, 3 were embodied by SCI, another review for.our studies win an international academic first prize.

以动物行为学、电生理学、神经药理学和免疫组织化学的方法证明，阿片肽、5-.羟色胺（5-HT）、谷氨酸，γ-氨基丁酸（GABA）神经递质及其受体参与介导丘脑中.央下核（Sm）的抗伤害感受效应，并支持如下假设：阿片肽、5-HT 诱发的抗伤害.感受效应可能是通过抑制GABA 能中间神经元对投射神经元的抑制作用，导致了激.活丘脑中央下核-腹腹外侧眶皮层-导水管周围灰质通路，进而激活脑干下行抑制系.统，在脊髓水平抑制伤害感受性输入而实现的；兴奋性谷氨酸递质经其受体介导可.能直接激活该通路的活动并产生抗伤害感受效应，而GABA 及其受体可能对该通路.施加抑制性影响。本研究为前-丘脑参与痛觉调制的神经递质与受体机制提供了重要.资料，具有重要的理论意义和潜在的应用前景。在国内外杂志和学术会议发表论文.19 篇，其中3 篇被SCI 收录，1 篇研究综述获2001 年国际学术奖。