一种新型CC家族趋化因子的抗肿瘤作用及其机理的研究

The effects of MIP-2γ on anti-tumor immunity and its related immunological mechanisms were observed. The results showed that intratumoral injection of recombinant MIP-2γ augmented preferable infiltration of CD8+ T cells in local and distant tumor site. Neutrophils infiltration induced by MIP-2γ increased in the tumor site as shown in histological sections. Using the leukemia virus-based retroviral vector pLXSN, we constructed a pL-MIP-2γ-SN vector and used it to transfer MIP-2γ into CT26 cells. The in vitro growth of MIP-2γ-CT26 cells could not be obviously affected, but the migration responses of MIP-2γ-CT26 cells to chemokines increased. mmunization with MIP-2γ-CT26 cellular vaccine was more efficacious than that of the controls.

本室新近从树突状细胞中克隆到一种与MIP-2家族成员有较高同源性的新型CC趋化因子（暂狹IP-2r）。该类蛋白主要趋化巨噬细胞、淋巴细胞、中性粒细胞，在肿瘤治疗中具有痹诘挠τ眉壑怠Ｎ颐悄庵刈楸泶锔眯滦颓骰蜃硬菇ㄆ渲刈橄俨《荆≡馛T26结肠腺癌Ｐ托懈骨缓土瞿诹鲋茏⑸洌鄄炱淇怪琢鲂Ч⑻教制溆泄氐拿庖呋恚琢鲋瘟铺剿餍峦揪丁