手性金属有机框架材料的设计、合成及其手性药物和手性中间体对映选择性分离性能研究

Porous metal-organic frameworks (MOFs) have emerged as a new class of porous solid materials based on their potential applications in selective separations and purifications. Compared with the traditional inorganic materials, one of the most significant superiority for these materials is that the framework structure and the pore properties of MOFs can be engineered and tailored by the judicious selection of organic ligands with various geometries or functional groups. In this project, we select a series of novel organic ligands can be easily chiral functionalized to design and prepare novel coordination compounds and discover new chiral porous materials; Simutaneously, in combination with the use of high performance liquid chromatographic technique, we would investigate the enantioselective separation of chiral pharmaceuticals (such as ascorbic acid which can adjust immunity and its enantiomer) or racemic chiral pharmaceutical intermediates (such as mandelic acid and 4-Hydroxyphenylglycine) with rich interaction sites. This research will provide new strategies for the development of novel practical chiral porous chromatogram immobility materials and the high-efficiency enantioselective separation of chiral pharmaceuticals or chiral pharmaceutical intermediates.

多孔配位聚合物，有时也被称为金属－有机框架材料，是一类具有识别和分离功能的新型多孔材料，可以通过丰富有机配体选择或官能团的引入实现孔道或孔壁性质的调控是多孔配位聚合物相对于传统无机多孔材料最显著的优势之一。本项目拟选用易于手性官能化（手性基团种类可变、手性中心个数可调等）的不同长度、不同刚柔性的有机桥联配体与不同过渡金属离子组装，构筑系列新颖手性多孔配位聚合物，结合高效液相色谱技术开展具有丰富作用位点的布洛芬等抗炎类、维Ｃ等增强机体免疫力类、对氯苯丙胺等增强中枢兴奋类手性药物的外消旋体和扁桃酸、对羟基苯苷氨酸等小分子外消旋药物中间体的手性分离性能研究。该研究将为实用性新型手性分离多孔色谱固定相材料研究及手性药物和中间体高效分离提供新策略和新途径。

多孔金属有机框架因其在吸附、分离、化学传感、磁性和催化等方面的潜在的应用价值引起了各国科学家的广泛关注。基于该类材料组成可调、比表面积大和孔壁可修饰等优点，本项目以构筑新颖的聚合结构、筛选合适的手性色谱填料、发现新的构效关系并开发新型功能材料为目的，选用一系列单/双/多羧酸桥联配体与不同过渡金属离子组装，构筑了一系列手性和非手性金属有机框架，并成功实现了相应的手性化合物高效液相分离及手性识别与细胞成像等新功能研究。该项目已取得了可观的阶段性成果，该成果为新型手性类分子筛色谱填料、手性识别材料、荧光探针及磁性材料的开发提供了新策略和新途径。